Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
N,2,3-Trimethyl-2-isopropylbutamide
1. Basic Information
Name: N,2,3-Trimethyl-2-isopropylbutamide
Alias: WS-23, 2-Isopropyl-N,2,3-trimethylbutyramide, Methyl diisopropyl propionamide
CAS No.: 51115-67-4
Molecular Formula: C10H21NO
Molecular Weight: 171.28
Category: Synthetic cooling agent (TRPM8 agonist), flavor & fragrance raw material, oral care/cosmetic additive, food flavoring agent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Mild pure mint cool aroma, no bitter pungent taste of menthol
- Solubility: Slightly soluble in water; freely soluble in ethanol, propylene glycol, glycerin, PG/VG, acetone; soluble in vegetable oil
- Melting Point: 60–63 ℃
- Boiling Point: 233 ℃ (760 mmHg); 85 ℃ (0.4 mmHg vacuum)
- Flash Point: 132 ℃
- Density (predicted): 0.89 g/cm3
- Hygroscopy: Non-hygroscopic under normal storage environment
- Aqueous property: Neutral fatty amide, stable in neutral water, no hydrolysis at room temperature
Chemical Properties
- Molecular structure: Branched aliphatic tertiary substituted amide, N-methyl substituted amide structure, long-lasting cooling stimulation to oral and skin mucosa
- Cooling characteristic: High-efficiency TRPM8 cold receptor agonist, mild cool feeling without burning/stinging irritation, cooling duration up to 15–30 minutes
- Thermal stability: Stable below 200 ℃, resistant to high-temperature baking and formula processing, no loss of cooling effect
- Chemical stability: Inert to weak acid and weak alkali; only slow hydrolysis under strong acid/strong alkali high-temperature reflux
- Photostability: Slightly light-sensitive; long-term direct sunlight will slightly turn pale yellow
- Compatibility: Well compatible with menthol, mint flavors, food emulsifiers, cosmetic substrates; incompatible with concentrated strong acid, strong oxidants
3. Main Application Fields
1. Oral Care Raw Material (Core Application)
Cooling additive for toothpaste, mouthwash, chewing gum, candy; cover bitter taste, provide soft long-lasting fresh feeling
2. Food & Beverage Flavor
Used in ice drinks, mint candies, baked food to prepare ice cool flavor system
3. Cosmetic & Personal Care Additive
Cool soothing ingredient for facial lotion, body cream, cooling gel, shaving products, relieve skin hot feeling
4. E-liquid & Tobacco Flavor
Add ice cool sensation for e-cigarette liquid, cigarette flavoring, reduce throat irritation
5. Topical Pharmaceutical Auxiliary
Sensory improver for external ointment, spray, improve user comfort of topical preparations
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 51115-67-4 |
| Molecular Formula | C10H21NO |
| Appearance | Uniform white crystal powder without discoloration |
| GC Purity | Food/Cosmetic Grade ≥99.0%, Industrial Grade ≥98.0% |
| Melting Point | 60–63 ℃ |
| Water Content (KF) | ≤0.50% |
| Acid Value | ≤10 mgKOH/g |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Light-proof aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, avoid direct strong light and heat source |
| Transportation Requirement | Slightly light-sensitive cooling agent crystal, conventional moisture-proof sealed packaging, separate from strong oxidants |
| Shelf Life | 36 months under fully sealed storage |
