Pregabalin
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
159.23
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Pregabalin
1. Basic Information
Name: Pregabalin
Alias: (S)-3-(Aminomethyl)-5-methylhexanoic acid, Lyrica
CAS No.: 148553-50-8
Molecular Formula: C8H17NO2
Molecular Weight: 159.23
Category: Chiral γ-aminobutyric acid analog, prescription pharmaceutical API
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in acetone; insoluble in non-polar solvents (hexane, toluene)
- Melting Range: 186–188 °C
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous Property: Amphoteric compound, isoelectric point near pH 6.0, aqueous solution neutral to weakly acidic
Chemical Properties
- Molecular Structure: Single S chiral center, contains primary amino group and carboxylic acid group, linear aliphatic skeleton
- Amphoterism: Forms soluble salts with inorganic acids and strong bases; can undergo esterification, amide coupling, Boc/Fmoc amino protection
- Optical stability: Stable under normal sealed dark storage; racemization only occurs under extreme high temperature + strong alkaline conditions
- Thermal Stability: Stable below 170 °C; melting with decomposition above melting point
- Photostability: Moderately light-sensitive; long-term UV exposure generates trace degradation impurities
- Compatibility: Compatible with aqueous buffer, alcohol solvents; incompatible with strong oxidants, acid chlorides, heavy metal ions
3. Main Application Fields
1. Prescription API Raw Material (Core Application)
Clinical therapeutic drug for neuropathic pain, generalized anxiety disorder, partial epilepsy, fibromyalgia; binds to voltage-gated calcium channels to relieve nerve excitability
2. Chiral Pharmaceutical Reference Standard
HPLC chiral standard for enantiomer purity detection in pregabalin production quality control
3. Neuroscience Research Reagent
Laboratory tool for studying calcium channel neurotransmission mechanisms
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 148553-50-8 |
| Molecular Formula | C?H??NO? |
| Appearance | Uniform white crystalline powder without discoloration impurities |
| HPLC Purity | Pharma Grade ≥99.5% |
| Enantiomeric Excess ee | ≥99.8% |
| Specific Optical Rotation [α]?2? | ?14.0° ~ ?16.0° (1% in water) |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bags / food-grade PE lined fiber drums |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, protected from light and moisture |
| Transportation Requirement | Light-sensitive chiral amino acid solid, moisture-proof light-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Low acute toxicity mild irritant pharmaceutical powder. Dust irritates eyes, nasal tract and respiratory tract; long-term repeated skin contact may trigger mild allergic reactions. All operations must be performed in ventilated fume hoods with dust respirators and nitrile gloves. Strictly controlled prescription medicine, prohibited arbitrary oral administration without medical guidance. Waste liquid neutralized before discharge; solid waste classified as pharmaceutical hazardous waste and disposed by licensed professional institutions.
