QUININE HCL
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
364.88
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Uniform white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Quinine Hydrochloride
1. Basic Information
Name: Quinine HCl / Quinine Hydrochloride
Alias: (8S,9R)-6'-Methoxycinchonan-9-ol hydrochloride
CAS No.: 130-89-2
Molecular Formula: C20H25ClN2O2
Molecular Weight: 364.88
Category: Natural cinchona alkaloid hydrochloride, antimalarial pharmaceutical raw material, chiral resolution reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White fine crystalline powder
- Odor: Odorless, extremely bitter taste
- Solubility: Soluble in water, ethanol, methanol; slightly soluble in chloroform; insoluble in ether, aliphatic hydrocarbons
- Melting Range: 158–160 °C (decomposes)
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous Property: Aqueous solution weakly alkaline, shows optical rotation
Chemical Properties
- Molecular Structure: Chiral bicyclic quinoline alkaloid combined with hydrochloric acid salt; contains two chiral centers, optical active
- Optical activity: Specific rotation [α]?2? ?133° ~ ?137° (water solution), core feature for chiral resolution
- Salt dissociation: Free quinine base precipitates when adding strong alkali to aqueous solution
- Fluorescence characteristic: Aqueous solution emits blue fluorescence under ultraviolet light
- Thermal stability: Stable below 140 °C; high temperature decomposes to release toxic nitrogen heterocyclic fumes
- Photostability: Light-sensitive; long-term UV irradiation causes yellow discoloration and activity decline
- Compatibility: Compatible with dilute acid aqueous solvents; incompatible with strong alkalis, heavy metal salts, oxidants
3. Main Application Fields
1. Antimalarial API Raw Material (Core Application)
Classic drug for treatment of Plasmodium falciparum malaria; also used for relieving muscle cramps
2. Chiral Resolution Reagent
Industrial separation of chiral carboxylic acid, amino acid enantiomers in fine chemical & chiral drug synthesis
3. Laboratory Analytical Reagent
Fluorescence indicator, chromatographic reference standard for alkaloid detection
4. Beverage Food Additive
Low-dose bitter flavoring for tonic water (strict dosage limited by food safety standards)
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 130-89-2 |
| Molecular Formula | C??H??ClN?O? |
| Appearance | Uniform white crystalline powder without yellow impurities |
| HPLC Purity | Pharma Grade ≥99.0% |
| Specific Optical Rotation | ?133° ~ ?137° |
| Water Content (KF) | ≤0.50% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber glass bottles / vacuum aluminum foil bags |
| Storage Condition | Hermetically sealed cool dark warehouse below 25 °C; shield from light and moisture |
| Transportation Requirement | Light-sensitive alkaloid solid, light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Toxic bitter alkaloid powder. Dust irritates eyes, respiratory tract and skin; excessive oral intake causes tinnitus, blurred vision, cardiac arrhythmia (quinine toxicity). All operations must be carried out in ventilated fume hood with dust respirators and chemical-resistant gloves. Strictly control exposure dosage; avoid mixing with strong alkali to separate free toxic quinine base. Waste liquid neutralized before discharge; solid waste classified as pharmaceutical hazardous waste disposed by licensed professional institutions.
