L-4-Iodophenylalanine
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
291.09
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
L-4-Iodophenylalanine
1. Basic Information
Name: L-4-Iodophenylalanine
Alias: 4-Iodo-L-phenylalanine, p-Iodo-L-phenylalanine
CAS No.: 24250-85-9
Molecular Formula: C9H10INO2
Molecular Weight: 291.09
Category: Iodinated chiral aromatic amino acid, peptide & biochemistry research intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water; soluble in dilute acid, dilute alkali, DMSO; hardly soluble in methanol, ethanol, acetone, ethyl acetate
- Melting Range: 262–266 °C (decomposes upon melting)
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous Property: Amphoteric compound, isoelectric point near pH 5.5, low aqueous solubility
Chemical Properties
- Molecular Structure: L-phenylalanine skeleton with iodine substitution at para-position of benzene ring, fixed L chiral configuration at α-carbon
- Amino & Carboxyl Amphoterism: Can form salts with acid/base; capable of Boc/Fmoc protection, peptide condensation, esterification for peptide synthesis
- Aryl Iodide Reactivity: Para C–I bond participates in Suzuki, Heck, Sonogashira cross-coupling to introduce fluorescent groups, isotopic markers
- Thermal Stability: Stable below 220 °C; high temperature decomposes, releases iodine vapor
- Photostability: Highly sensitive to UV light; long-term illumination causes deiodination and yellow discoloration
- Compatibility: Compatible with peptide synthesis anhydrous solvents; incompatible with strong reducing agents, concentrated strong alkali, heavy metal salts
3. Main Application Fields
1. Peptide & Protein Labeling Research (Core Application)
Non-natural amino acid for site-specific protein modification; iodine atom serves as heavy atom marker for X-ray crystallography protein structure analysis
2. Chiral Pharmaceutical Intermediate
Building block for iodinated polypeptide drugs, enzyme inhibitors, targeted small molecule therapeutics
3. Biochemical NMR/Mass Spec Standard
Isotope precursor and chromatographic reference standard for amino acid derivative detection
4. Organic Cross-Coupling Substrate
Aryl iodide monomer for synthesizing fluorescent biological probes
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 24250-85-9 |
| Molecular Formula | C9H10INO2 |
| Appearance | Uniform white crystalline powder without brown deiodination impurities |
| HPLC Purity | Biochemical Grade ≥99.0%; Reference Standard ≥99.5% |
| Optical Rotation [α]D20 | -16.0 ~ -19.0 (c=2, 1M HCl) |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber glass vials / vacuum aluminum foil bags |
| Storage Condition | Hermetically sealed cool dark warehouse below 25 °C; strictly shielded from light, isolate from reducing substances |
| Transportation Requirement | Light-sensitive iodinated amino acid solid, moisture-proof light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum sealed storage |
Safety Warning
Mild irritant iodinated amino acid powder. Dust irritates eyes, respiratory tract and skin; long-term contact may cause mild skin allergy. All operations must be performed in ventilated fume hoods with dust respirators and chemical-resistant gloves. Avoid contact with strong reducing agents to prevent toxic iodine release. Waste liquid neutralized before solvent recovery; solid waste classified as organic hazardous waste and handled by licensed professional disposal institutions.
