Ibuprofen
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
206.28
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Ibuprofen
Alias: 2-(4-Isobutylphenyl)propanoic acid
CAS No.: 15687-27-1
Molecular Formula: C13H18O2
Alphabet-number format molecular formula: C13H18O2
Molecular Weight: 206.28
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slight bitter taste
- Solubility: Insoluble in water; freely soluble in ethanol, acetone, dichloromethane, ether; slightly soluble in dilute alkaline aqueous solution
- Melting Point: 75–78 °C
- Hygroscopicity: Non-hygroscopic under normal ambient humidity
- Crystal characteristic: Flaky crystal after recrystallization from hexane
Chemical Properties
- Molecular Structure: Aryl propionic acid NSAID, contains benzene ring, isobutyl substituent and carboxyl functional group
- Acid-base reactivity: Carboxyl group reacts with alkalis to form soluble ibuprofen salt (sodium ibuprofen, lysine ibuprofen)
- Esterification reaction: Carboxyl group can undergo esterification with alcohols to prepare ibuprofen ester prodrugs
- Thermal stability: Stable below 100 °C; obvious thermal decomposition above 200 °C
- Photostability: Slightly sensitive to strong UV light; long-term light exposure turns pale yellow
- Compatibility: Compatible with neutral excipients, lipid raw materials; incompatible with strong oxidants, concentrated strong bases and heavy metal ions
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Nonsteroidal anti-inflammatory active ingredient for oral tablets, granules, suspensions, soft capsules
- Clinical uses: relieve fever, mild-moderate pain (headache, dysmenorrhea, arthralgia), treat rheumatoid arthritis and soft tissue inflammation
- Raw material for compound cold medicines and external pain-relieving ointments
2. Pharmaceutical Intermediate
Starting material for synthesizing ibuprofen salt derivatives with better water solubility and faster absorption
3. Analytical Reference Standard
HPLC calibration standard for quality control testing of ibuprofen pharmaceutical preparations
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 15687-27-1 |
| Molecular Formula | C13H18O2 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Melting Point | 75–78 °C |
| Water Content (KF) | ≤0.50% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic cool dark warehouse below 25 °C; segregated from oxidants and alkaline materials |
| Transportation Requirement | Low-toxic pharmaceutical solid, dust-proof light-resistant sealed packaging |
| Shelf Life | 36 months under intact sealed packaging |
Safety Warning
Low acute toxicity, but oral overdose causes gastrointestinal irritation, renal discomfort. Dust inhalation irritates eyes and respiratory tract; wear dust mask and chemical-resistant gloves during operation. Avoid long-term exposure to strong light and high temperature to prevent oxidative degradation. Waste residues and waste liquid belong to pharmaceutical organic hazardous waste and require professional centralized disposal.
