1. Basic Product Profile

• Full IUPAC Name: 2-methyl-5-nitroimidazol-1-ethanol
• Aliases: Metronidazole, Flagyl
• CAS Number: 443-48-1
• EINECS: 206-415-2
• Molecular Formula: C6H9N3O3
• Molecular Weight: 171.16
• Chemical Classification: Nitroimidazole antibacterial & antiprotozoal API, pharmaceutical raw material
• Core Advantages
  Classic nitroimidazole broad-spectrum antimicrobial agent. Effective against anaerobic bacteria, trichomonas, amoeba and giardia. Stable chemical property, good oral absorption, compliant with USP/EP pharmacopoeia standards. Used for oral tablets, injections, topical creams, gynecological suppositories and veterinary antibacterial preparations.

2. Physical & Chemical Properties

2.1 Physical Index

1. Appearance: White to pale yellow crystalline powder
2. Odor: Odorless, slightly bitter taste
3. Solubility: Slightly soluble in water; soluble in ethanol, methanol, chloroform; insoluble in aliphatic hydrocarbons
4. Melting Point: 158–160 °C
5. Specific Optical Rotation: Optical inactive
6. Aqueous suspension pH: 4.5–6.0 (weakly acidic)
7. Hygroscopy: Non-hygroscopic under normal dry storage

2.2 Chemical Properties

1. Nitroimidazole ring core: Nitro group undergoes reduction under anaerobic environment to generate active metabolites that damage microbial DNA and inhibit reproduction
2. Hydroxyl ethyl side chain: Can perform esterification reaction to prepare metronidazole derivatives
3. Acid & Alkali Stability: Stable under neutral and weak acidic conditions; decomposes under strong alkaline heating
4. Thermal Stability: No obvious decomposition below 140°C
5. Photostability: Sensitive to strong UV light; long-term illumination darkens and produces related impurities
6. Compatibility: Compatible with most neutral pharmaceutical excipients; incompatible with strong alkali, strong oxidants

3. Main Application Fields

3.1 Human Pharmaceutical API (Core Usage)

1. Treat anaerobic bacterial infections in abdominal cavity, oral cavity, gynecology and skin;
2. Therapeutic drug for trichomoniasis, intestinal and hepatic amoebiasis, giardiasis;
3. Raw material for topical anti-inflammatory cream, gynecological suppository and mouthwash.

3.2 Veterinary Antibacterial Raw Material

3.3 Pharmaceutical Reference Standard

3.4 Fine Chemical Intermediate

4. Quality Specification Table