Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Information
- Full Name: 2,4,5-Trifluorophenylacetic acid
- Aliases: 2-(2,4,5-Trifluorophenyl)acetic acid
- CAS No.: 209995-38-0
- EINECS No.: N/A
- Molecular Formula: C8H5F3O2
- Molecular Weight: 190.12
- Chemical Classification: Fluorinated aromatic fine chemical, pharmaceutical intermediate, pesticide synthetic building block
- Core Product Features
High-purity fluorinated benzoacetic acid derivative; stable aromatic fluorine structure, high chemical inertness; contains reactive carboxyl group for esterification, amidation and condensation reactions; low residual fluorine impurities, widely used in new drug R&D, agrochemical synthesis and liquid crystal material production.
2. Detailed Physical & Chemical Properties
2.1 Physical Properties
- Appearance: White crystalline powder, uniform fine particles, no caking and foreign impurities
- Odor: Slight weak acid odor
- Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate, dichloromethane; slightly soluble in hot water; insoluble in n-hexane and other aliphatic hydrocarbons
- Melting Point: 108–112℃
- Boiling Point: Decompose above 260℃, no fixed boiling point under normal pressure
- pH (saturated aqueous suspension): Weak acidity
- Hygroscopicity: Slightly hygroscopic, need sealed storage to avoid moisture absorption
2.2 Chemical Properties
- Fluorine Substitution Structure: Three fluorine atoms on benzene ring enhance metabolic stability of downstream drug molecules, improve lipid solubility
- Carboxyl Reactivity: Carboxyl group can react with alcohols, amines to generate ester and amide intermediates; can form salt with inorganic alkali
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; neutralized and dissolved in strong alkali aqueous solution; long-time strong alkali heating will cause partial defluorination degradation
- Photostability: Stable under indoor light; long-term strong ultraviolet exposure leads to slow oxidation discoloration
- Compatibility: Compatible with most conventional pharmaceutical solvents; incompatible with strong oxidants and strong reducing agents
3. Comprehensive Product Applications
3.1 Pharmaceutical Intermediate (Main Application)
Key fluorinated aromatic building block for synthesis of anti-inflammatory, anti-viral, anti-diabetic and central nervous system drugs. The trifluorophenyl structure can significantly improve drug cell membrane permeability and metabolic half-life, widely used in laboratory and pilot-scale pharmaceutical synthesis.
3.2 Agrochemical Intermediates
Raw material for high-efficiency low-toxicity herbicides, fungicides and insecticides; fluorinated aromatic groups improve pesticide absorption by crops and reduce environmental residue.
3.3 Liquid Crystal & Electronic Materials
Synthetic monomer for fluorinated liquid crystal compounds, used to adjust dielectric constant and low-temperature fluidity of liquid crystal mixtures.
3.4 Biochemical Research Reagents
Standard fluorinated aromatic reagent for organic synthesis labs, used for developing fluorine-containing probe molecules and enzyme inhibitors.
4. Full Parameter Specification Table
| Item | Detailed Standard Specification |
| CAS No. | 209995-38-0 |
| Molecular Formula | C8H5F3O2 |
| Molecular Weight | 190.12 |
| Appearance | White crystalline powder |
| Melting Point | 108–112℃ |
| Boiling Point | Decompose over 260℃, no fixed boiling point |
| HPLC Purity | ≥99.0% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metal (Pb) | ≤10 ppm |
| Bulk Packaging | 25kg aluminum foil lined fiber drum |
| Sample Packaging | 10g / 100g / 1kg sealed aluminum foil bag |
| Storage Condition | Sealed, cool dry warehouse below 25℃; away from strong light, strong alkali and oxidants |
| Transportation Standard | General organic fine chemical, non-dangerous goods; waterproof packaging during transit |
| Shelf Life | 24 months under intact original sealed packaging |
