4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
153.57 g/mol
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
CAS Number: 3680-69-1
Alias: 6-Chloro-7-deazapurine
Molecular Formula: C6H4ClN3
Molecular Weight: 153.57 g/mol
Structural Information
- Structure Type: Heteroaromatic compound, a key scaffold in medicinal chemistry.
- Structural Features: Fused pyrrole-pyrimidine ring system with a chlorine atom at the 4-position. Exhibits aromaticity and multiple hydrogen-bonding sites, enabling interactions with various biological targets.
Physical & Chemical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Melting Point: 188–194 °C
- Boiling Point: 289.2±50.0 °C (Predicted)
- Density: 1.61±0.1 g/cm3 (Predicted)
- Solubility: Soluble in DMSO, DMF, methanol and ethyl acetate; sparingly soluble in water
- Stability: Stable under sealed and low temperature conditions. Avoid exposure to strong light, high temperature and strong oxidants.
Synthesis & Applications
Synthesis Method
Prepared via multi-step cyclization and chlorination reactions using common aliphatic and heterocyclic raw materials. The crude product is purified by recrystallization to obtain high-purity finished product.
Main Applications
- Pharmaceutical industry: Important heterocyclic intermediate for the synthesis of JAK inhibitors, anti-tumor and anti-inflammatory drugs.
- Biochemical research: Used as tool reagent for kinase pathway research and purine metabolism related experiments.
- Organic synthesis: Widely applied to construct fused heterocyclic compound libraries in drug development.
Safety & Storage Instructions
- Hazard Classification: Moderate toxicity, irritant to skin, eyes and respiratory tract
- Personal Protection: Wear chemical resistant gloves, safety goggles and dust mask. Operate in fume hood, avoid inhalation and direct contact.
- Storage Condition: Keep containers tightly sealed. Store at 2–8 °C in cool, dry and dark environment. Keep away from oxidants and heat sources.
- Transportation: General fine chemical products. Prevent package damage, moisture and high temperature during transit.
Quality & Spectral Data
- Purity (HPLC): ≥98.0% / ≥99.0%
- Loss on Drying: ≤0.5%
- Residue on Ignition: ≤0.1%
- 1H NMR Spectrum: Consistent with standard reference spectrum
- IR Spectrum: Characteristic absorption peaks match the standard structure
Information Summary Table
| Item | Specification |
| CAS Number | 3680-69-1 |
| Product Name | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine |
| Synonym | 6-Chloro-7-deazapurine |
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Appearance | White to off-white crystalline powder, odorless |
| Melting Point | 188–194 °C |
| Solubility | Soluble in DMSO, DMF, methanol, ethyl acetate; sparingly soluble in water |
| Purity | ≥98.0% / ≥99.0% (HPLC) |
| Storage Condition | Sealed, 2–8 °C, cool dry and dark place |
| Hazard Property | Moderate toxicity, irritant |
| Main Usage | Pharmaceutical intermediate, biochemical reagent, organic synthesis raw material |
