Batch NO.:PYR-260605 Assay(HPLC):≥99.0% Loss on Drying:≤0.25% Residue on Ignition:≤0.10% Single unknown impurity:≤0.15% Total impurities:≤0.40% Heavy Metals(Pb/As/Cd):＜10ppm

This halogenated pyrimidine-pyrazole fused heterocyclic intermediate is a core building block for targeted small-molecule drug synthesis, mainly applied in kinase inhibitor, anti-tumor and anti-inflammatory pharmaceutical R&D fields. The reactive C-Cl on pyrimidine ring undergoes nucleophilic substitution with amines, alcohols or arylboronic acids via Suzuki coupling; iodine substituent on pyrazole ring also supports cross-coupling reactions to construct diversified molecular skeletons for novel candidate APIs. Medicinal chemistry laboratories adopt this raw material to develop JAK, CDK and BTK series targeted inhibitor precursors for preclinical pharmacology screening. Fine chemical custom synthesis factories utilize it for downstream derivatization into clinical trial intermediate compounds. Analytical standard grade is prepared as reference substance for HPLC detection of related intermediate residues in synthetic process control. It is exclusively for lab pharmaceutical synthesis use, forbidden for food, feed and direct human medication formulation.

GHS irritant substance with hazard codes H315 (skin irritation), H319 (serious eye damage), H335 (respiratory tract irritation from inhaled dust). All weighing and material feeding operations must be performed inside ventilated fume cupboard; operators equip nitrile gloves, full-face splash goggles and dustproof lab coat to prevent crystal dust contact with skin and respiratory tract. In case of skin contact, flush affected area with plenty of soap and running water for minimum 15 minutes; continuously irrigate eyes with abundant clean water over 15 min once splashing occurs and visit ophthalmologist for persistent discomfort. Accidental oral ingestion may trigger stomach upset and nausea; large-dose intake requires prompt hospital symptomatic treatment. Waste solid residues and contaminated filter scraps are classified as lab hazardous chemical waste, delivered to certified waste disposal institution per local environmental laws, strictly prohibited to discharge into sewer system. Keep separately stored with strong reducing agents and strong alkaline reagents to avoid dehalogenation decomposition.