This phosphorylated creatinine derivative is a critical pharmaceutical intermediate and creatinine related impurity reference standard used in biochemistry and API synthesis research, not applicable for food or direct clinical usage. Primarily applied as key precursor for phosphocreatine bulk drug manufacturing via debenzylation hydrogenolysis reaction; catalytic hydrogenation removes two benzyl protecting groups to yield phosphocreatine, a core cardiac and muscle nutrition raw material in pharmaceutical industry. High-purity certified grade works as reference substance for HPLC analysis during creatinine injection and phosphocreatine API impurity detection in pharmaceutical QC labs and third-party CRO testing institutions. In biochemical research field, it is used for animal cell metabolism experiment exploring creatine phosphate metabolic pathway, also adopted in custom fine chemical synthesis for novel phosphorylated imidazoline derivative development via phosphoramidate hydrolysis and derivatization reactions. Partial small batch is supplied to diagnostic reagent factories for creatinine assay kit raw material research.
Classified as GHS Warning irritant with H315 skin irritation, H319 serious eye irritation, H335 harmful if inhaled dust. All operators must equip nitrile chemical resistant gloves, full-face safety goggles and dustproof lab coat during sampling, weighing and solution preparation to avoid direct contact and dust inhalation. Upon skin splash, rinse contaminated skin with abundant running tap water for minimum 15 minutes; continuously flush eyes over 15 min once eye contact occurs, seek medical care if irritation persists. Accidental oral intake may induce mild gastrointestinal upset, nausea; large dosage ingestion requires prompt hospital treatment. All residual solid waste and organic waste liquid containing this phosphoramidate compound shall be categorized as general chemical hazardous waste, delivered to authorized professional waste disposal plant following local environmental law, strictly prohibited from draining into sewer or domestic trash. Store separately from concentrated mineral acid, strong alkaline and peroxide oxidants to prevent hydrolytic decomposition and toxic phosphorous-containing byproducts generation.
