N-Acetylglycine is an important modified amino acid widely applied in pharmaceutical intermediate, biochemical reagent and food additive industries. In pharmaceutical synthesis, it is the core starting raw material for preparing cephalosporin antibiotics and various peptide medicines via condensation and cyclization reactions, playing an essential role in the production of β-lactam series drugs. For biochemical research, it is used as standard reference substance for amino acid metabolism research and cell culture medium additive to explore enzyme catalytic mechanism of acetyltransferase. In food and health care field, it serves as nutritional fortifier and raw material of compound amino acid supplements to improve human amino acid absorption efficiency. Besides above usage, it is adopted as organic synthesis building block for manufacturing fine chemicals and cosmetic active ingredients. Its stable chemical property and mature production process make it a commonly used bulk fine chemical across pharmacy, biochemistry and food processing sectors.
GHS Classification: H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation). Signal Word: Warning. Acute oral LD50 of rat is higher than 5000 mg/kg with extremely low acute toxicity. Short-time skin contact brings slight redness and itch; continuous long-term exposure may trigger mild irritant dermatitis and needs timely water cleaning. Splashing into eyes leads to obvious stinging and conjunctival hyperemia requiring continuous flushing with plenty of clean water for over fifteen minutes. Inhalation of floating fine dust irritates nasopharyngeal mucosa and causes intermittent cough and throat discomfort. Existing long-term toxicology experiments do not confirm carcinogenic, mutagenic or reproductive toxic hazards of this product. It has minor adverse effect on aquatic organisms, arbitrary discharge into rivers or soil is forbidden strictly. All operational procedures should be finished under well ventilated environment; operators wear nitrile gloves, splash-proof goggles and dust-proof mask. Store separately from strong alkali and strong oxidants; waste residues are treated in accordance with local environmental protection and hazardous waste disposal regulations.
