Cyclohexanecarboxaldehyde is a versatile aliphatic aldehyde intermediate widely used in organic synthesis, pharmaceutical, fragrance, and agrochemical industries. Its reactive aldehyde group enables condensation, reduction, and oxidation reactions to build complex molecules. In pharmaceutical synthesis, it serves as a key precursor for producing antihistamines, analgesics, and CNS agents by forming cyclohexyl-containing scaffolds that enhance lipophilicity and metabolic stability. In fragrance industry, it imparts fresh, green, and woody notes to perfumes and cosmetics, often used in soap and detergent fragrances. It is also a critical intermediate for synthesizing cyclohexylamine derivatives, which are used in rubber vulcanization accelerators and corrosion inhibitors. Additionally, it acts as a flavoring agent in food additives and a cross-linking agent in polymer manufacturing. Its high purity and well-defined reactivity make it essential for fine chemical production and academic research.
GHS Classification: H226 (Flammable liquid and vapor), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation). Signal Word: Warning. UN Number: UN1989. Acute toxicity: Oral LD50 (rat) >2,000 mg/kg (low toxicity); no significant dermal toxicity data. Skin contact: May cause redness, itching, and mild dermatitis; prolonged exposure may lead to dryness and cracking. Eye contact: Causes severe irritation, tearing, and potential corneal damage; requires immediate flushing with plenty of water for 15 minutes. Inhalation: Vapors may irritate the respiratory tract, causing coughing, sore throat, or shortness of breath; high concentrations may induce dizziness or headache. Ingestion: May cause gastrointestinal discomfort, nausea, or vomiting; no evidence of carcinogenicity, mutagenicity, or reproductive toxicity. Environmental hazard: WGK 1 (Slightly harmful to aquatic organisms); avoid release into waterways. Handling: Use in a fume hood with nitrile gloves, safety goggles, and a vapor respirator; keep away from open flames, sparks, and heat sources. Storage: Seal tightly in a cool, dry place at 2–8 °C under inert gas, away from oxidants and strong bases. Spills: Absorb with inert materials (sand, vermiculite), collect in sealed containers, and dispose of as hazardous waste; rinse affected skin/eyes with plenty of water.
