Tris(pentafluorophenyl)borane (B(C?F?)?) is a superior Lewis acid catalyst with exceptional electrophilicity and thermal stability. It serves as a key cocatalyst in olefin polymerization, activating metallocene catalysts by abstracting anionic ligands to form cationic metal centers stabilized by non-coordinating borate anions. In organic synthesis, it catalyzes Piers–Rubinsztajn reactions, enabling mild, high-yield siloxane bond formation between hydrosilanes and alkoxysilanes. It promotes hydride transfer, borylation, hydrogenation, and hydrosilylation reactions, even in aqueous conditions. In materials science, it acts as a p-type dopant for organic semiconductors in OFETs and OPVs, enhancing charge transport and stability. It also passivates perovskite solar cell surfaces, improving efficiency and longevity. Additionally, it is used in frustrated Lewis pair (FLP) chemistry and as a reagent for preparing organometallic complexes.

GHS Classification: Warning Hazard Statements: H315 (Causes skin irritation); H319 (Causes serious eye irritation); H335 (May cause respiratory irritation) This compound has low acute toxicity (oral LD50 >5000 mg/kg in rats) but irritates skin, eyes, and respiratory tract. Direct contact may cause redness, itching, and dry skin; eye exposure leads to stinging, tearing, and conjunctivitis. Inhalation of dust or fumes may trigger coughing, shortness of breath, or throat irritation. No evidence of carcinogenicity, mutagenicity, or reproductive toxicity exists under normal use. Handle in a fume hood with nitrile gloves, safety goggles, and a dust mask (N95). In case of skin contact, wash thoroughly with soap and water; for eye exposure, rinse continuously for 15 minutes and seek medical help if irritation persists. Store separately from strong bases and moisture. Dispose of waste per local regulations, avoiding release into the environment.