D-4-Chloromandelic acid (CAS 32189-36-9) is a high-value chiral intermediate widely used in pharmaceutical, agrochemical, and fine chemical synthesis. Its unique chiral structure with a chlorinated aromatic ring and a hydroxyl group enables it to serve as a key building block for producing chiral drugs, especially in the synthesis of anti-inflammatory, analgesic, and cardiovascular medications. In the agrochemical industry, it acts as an intermediate for manufacturing selective herbicides and fungicides with high bioactivity and low environmental impact. It is also utilized in organic synthesis for preparing chiral catalysts and resolving agents to separate racemic mixtures. Additionally, it functions as a raw material for synthesizing specialty dyes and fragrances. With its stable chemical properties and high chiral purity, this compound plays a critical role in the production of high-value-added fine chemicals, supporting the development of the pharmaceutical and agrochemical sectors.

This compound is classified as GHS07 Warning, causing skin, eye, and respiratory irritation. It may enter the body via inhalation, skin contact, eye contact, or ingestion. Acute oral toxicity is low, but ingestion may cause nausea, vomiting, abdominal discomfort, and diarrhea. Skin contact can trigger irritation, redness, itching, or mild allergic reactions in sensitive individuals; prolonged or repeated exposure may lead to skin dryness, cracking, or dermatitis. Eye contact results in severe irritation, tearing, conjunctival redness, and potential corneal damage if not promptly treated. Inhalation of dust or powder irritates the respiratory tract, causing cough, sore throat, chest tightness, or shortness of breath, particularly in poorly ventilated areas.

Handle in a well-ventilated fume hood. Wear nitrile gloves, splash-proof safety goggles, and a dust respirator. Avoid contact with strong oxidants, acids, and bases to prevent decomposition and toxic fume release. In case of skin contact, wash thoroughly with soap and running water for 15 minutes. For eye exposure, flush continuously with plenty of clean water for at least 15 minutes and seek immediate medical attention. If ingested, do not induce vomiting; rinse the mouth with water and seek medical help. Store sealed in a cool, dry place away from food, feed, and incompatible substances. For transportation, it is not classified as a dangerous good. Dispose of waste and containers in accordance with local environmental regulations to avoid water and soil contamination.