Detomidine hydrochloride is a potent α?-adrenergic receptor agonist and a key veterinary sedative-analgesic, mainly used in horses and large animals. It acts on central α? receptors to inhibit sympathetic activity, inducing dose-dependent sedation, analgesia and muscle relaxation. Clinically, it calms excitable horses, relieves abdominal pain, and aids minor surgeries (e.g., suturing, castration) and diagnostics (e.g., endoscopy, rectal palpation). It is also used as pre-anesthetic medication to reduce anesthetic dosage and stabilize anesthesia. In research, it serves as a tool for studying autonomic nervous system and pain mechanisms. Its high selectivity and rapid onset make it indispensable in equine veterinary medicine, with broad prospects in animal anesthesia and pain management.

This product is toxic via oral, skin and inhalation routes (GHS Category 3). Inhalation of dust causes respiratory irritation, headache and dizziness; wear a dust respirator and ensure good ventilation. Skin contact may cause poisoning and irritation; wear nitrile gloves and wash skin with soap and water thoroughly after contact. Eye contact leads to severe irritation, redness and pain; flush eyes with plenty of running water for ≥15 minutes and seek medical attention promptly. Ingestion causes nausea, vomiting, abdominal pain, bradycardia and respiratory depression; do not induce vomiting and call a physician immediately. It is stable at room temperature but incompatible with strong oxidants and strong acids. Store sealed in a cool, dry place, away from heat sources and incompatible substances. Dispose of waste per local hazardous waste regulations; do not discharge arbitrarily to avoid environmental pollution.