Methoxy polyethylene glycol amine is one of the most commonly used activated PEG derivatives in biomedical field. It retains excellent water solubility, low immunogenicity and good biocompatibility of polyethylene glycol chain, and the terminal primary amino group can stably react with carboxyl group, NHS ester, aldehyde group and other active groups to realize efficient chemical conjugation. It is widely applied in protein and polypeptide modification, antibody drug coupling and small molecule drug PEGylation modification, which can effectively prolong the in-vivo circulation time of drugs, reduce metabolic clearance rate and weaken immunogenic reaction. It is also used for surface modification of liposomes, microspheres and nano biomaterials to improve material dispersion and biological affinity. In addition, this product can be used to prepare biological hydrogels, biosensors and medical auxiliary materials, and also serves as an important carrier reagent in solid-phase synthesis and biological laboratory labeling experiments. It has stable reaction activity and mild reaction conditions, which can effectively maintain the biological activity of modified substances and meet various research and production demands in pharmaceutical research and clinical medical auxiliary fields.

This product is classified as mild irritant with low acute toxicity. Inhalation of its dust will cause slight irritation to human respiratory tract, leading to throat discomfort and cough, so ventilation operation and dust-proof protective mask are required during handling. Long-term or direct skin contact may cause skin dryness, redness and itching stimulation, operators need to wear nitrile protective gloves, and clean the contacted skin with clean water and soap in time after operation. Splashing into eyes will cause obvious stinging and tearing symptoms, once contact occurs, flush eyes with plenty of flowing clean water for more than 15 minutes and seek medical treatment promptly. Accidental ingestion may cause mild gastrointestinal discomfort, do not induce vomiting blindly and take medical measures as soon as possible. Under normal room temperature environment, the product has stable chemical properties, but it should be kept away from strong oxidants, strong acids and high temperature environment to prevent structural decomposition and performance change. It shall be stored in dry and sealed environment to avoid moisture absorption and deterioration. Waste materials and residual substances shall be disposed in accordance with local hazardous waste treatment regulations, and direct discharge into natural environment is strictly prohibited to avoid potential environmental pollution risks.