3,4-bis(2-Methoxyethoxy)benzaldehyde
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
Colorless to pale yellow oily liquid
|
| Storage |
Sealed, cool, dry, dark place (2–8 °C); avoid air oxidation
|
| aliasen |
|
| supplyCapacity |
50000Metric Ton/Month
|
| Solubility |
Soluble in ethanol, ethyl acetate, DMSO; slightly soluble in water
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
- Appearance: Colorless to pale yellow oily liquid
- Purity (HPLC): ≥99.0%
- Moisture (K.F.): ≤0.3%
- Refractive Index (n??/D): 1.485–1.495
- Heavy Metals (Pb): ≤5 ppm
- Related Substances: ≤0.2% (single impurity)
- Assay (Titration): 99.0%–101.0%
Applications
CAS 80407-64-3 is a critical pharmaceutical intermediate, most notably for synthesizing Erlotinib (Tarceva), a targeted anti-cancer drug for non-small cell lung cancer (NSCLC). It serves as a key building block in the drug’s aromatic ring construction, enabling the introduction of methoxyethoxy side chains essential for Erlotinib’s EGFR inhibitory activity. Beyond oncology, it’s used in fine chemical synthesis (e.g., 3,4-bis(2-methoxyethoxy)benzonitrile via oximation), perfume intermediates (aromatic aldehyde derivatives), and polymer additives (as a crosslinking agent precursor). In research, it acts as a chemical probe for studying aromatic substitution reactions and drug-target binding mechanisms.
Safety Information
Classified as GHS07 (Irritant); hazard statements H315 (Skin Irritation), H319 (Eye Irritation), H335 (Respiratory Irritation).
- Inhalation: Vapor irritates respiratory tract; use fume hood + organic vapor respirator.
- Skin Contact: May cause redness/itching; wear nitrile gloves, wash with soap/water.
- Eye Contact: Causes severe irritation; wear safety goggles, rinse eyes ≥15 min.
- Ingestion: Low acute toxicity (LD50 oral rat >5,000 mg/kg); do not induce vomiting, seek medical aid.
- Chemical Hazards: Stable under normal conditions; avoid strong oxidants, strong bases, and high temperatures (>150 °C) (risk of decomposition to toxic aldehydes); oxidizes slowly in air.
- Storage: Sealed under nitrogen, cool/dry/dark; separate from incompatible substances.
- Disposal: Dispose as hazardous waste per local regulations; incinerate in approved facility.
