(4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
Yellow viscous liquid
|
| Storage |
Sealed, dry, cool place (≤25 °C); avoid strong acid/oxidants
|
| aliasen |
|
| supplyCapacity |
50000Metric Ton/Month
|
| Solubility |
Soluble in chloroform, ethanol, acetone; slightly soluble in water
|
| harbor |
Qingdao,China
|
| Flash Point |
96.8 °C
|
| minorder |
1KG
|
- Appearance: Yellow viscous liquid
- Purity (HPLC): ≥98.0% (≥99.0% for pharma)
- Specific Rotation [α]D: -18° ~ -22° (c=1, CHCl?)
- Moisture (K.F.): ≤0.3%
- Residue on Ignition: ≤0.1%
- Single Impurity (HPLC): ≤0.5%
- Heavy Metals (Pb): ≤10 ppm
Applications
CAS 125995-13-3 (ATS-9) is a critical chiral intermediate for Atorvastatin Calcium (Lipitor), a blockbuster lipid-lowering drug. As the key side-chain building block, it undergoes condensation with the pyrrole core to form Atorvastatin’s skeleton, enabling large-scale industrial synthesis with high chiral purity (≥99% ee). Its 1,3-dioxane protecting group stabilizes the molecule during multi-step synthesis, while the aminoethyl and tert-butyl acetate moieties provide reactive sites for coupling and deprotection. Beyond statins, it serves as a chiral synthon for other pharmaceuticals, agrochemicals, and fine chemicals requiring 1,3-dioxane or aminoethyl chiral fragments. It is produced under GMP conditions for pharma use, with strict control of chiral impurities to ensure drug safety and efficacy.
Safety Information
Classified as GHS07 (Xi, Irritant); hazard statements H315 (Skin Irritation), H319 (Eye Irritation).
- Inhalation: Mist irritates respiratory tract; use fume hood and respiratory mask.
- Skin Contact: Causes redness/itching; wear nitrile gloves, wash skin with soap/water.
- Eye Contact: Severe irritation (tearing/stinging); wear safety goggles, rinse eyes ≥15 min.
- Ingestion: May cause nausea; do not induce vomiting, seek medical aid.
- Chemical Hazards: Stable under normal conditions; avoid strong acids, strong oxidants, high temperatures (>100 °C) (may trigger deprotection/decomposition).
- Storage: Keep in cool, dry, ventilated area in tightly sealed containers; separate from incompatible substances.
- Disposal: Dispose as hazardous waste per local regulations; avoid environmental release.
