Methyl 6-amino-5-bromonicotinate
- Createtime： 2026-04-14
- Updatetime： 2026-04-15
Product Details
| Boiling Point |
323.7 °C
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| deliveryInfo |
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| Molecular Weight |
231.05
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| Stability |
Stable under normal conditions; light-sensitive; avoid strong acids/bases
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| aliasen |
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| supplyCapacity |
50000Metric Ton/Month
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| Solubility |
Soluble in methanol, ethyl acetate, dichloromethane, DMSO, DMF; sparingly soluble in water
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| harbor |
Qingdao,China
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| minorder |
1KG
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| useage |
Industrial use
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| appearance |
Off-white to pale yellow crystalline powder
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| Storage |
Sealed, cool and dry, protect from light
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| Flash Point |
149.6 °C
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| Molecular Formula |
C?H?BrN?O?
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| Melting Point |
166–168 °C
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| Item | Specification |
| Assay (HPLC) | ≥98.0% (98–99% typical) |
| Appearance | Off-white to pale yellow crystalline powder |
| Melting Point | 165–169 °C |
| Water Content | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Single Impurity | ≤0.2% |
| Total Impurity | ≤1.0% |
| Identification (NMR/IR) | Conforms to standard |
Pharmaceutical Intermediate
- Heterocyclic Scaffold Synthesis: A trifunctional pyridine building block with amino, bromo, and methyl ester groups; critical for constructing fused pyridine systems (pyrido[2,3-d]pyrimidines, thieno[2,3-b]pyridines, furo[2,3-b]pyridines) in drug discovery.
- Cross-Coupling Reactions: The 5-bromo substituent enables Suzuki, Stille, Sonogashira, and Buchwald-Hartwig couplings; used to introduce diverse substituents for chemical library synthesis in anticancer, antifungal, and antibacterial drug development.
- Kinase/GPCR Modulator Precursors: Derivatives target key drug targets (kinases, GPCRs) due to their highly substituted heterocyclic cores; investigated for potential in oncology and infectious diseases.
Organic Synthesis
- Cyclocondensation Reactions: Amino and ester groups react with formamide/derivatives to form pyrimidine rings; used in synthesizing pyrido[2,3-d]pyrimidin-4(3H)-ones and related heterocycles.
- Functional Group Transformation: Methyl ester hydrolyzed to carboxylic acid; amino group modified via acylation/alkylation; bromo group substituted to generate diverse pyridine derivatives.
Material Science
- Luminescent Material Precursors: Used to synthesize pyridine-based conjugated polymers and OLED materials; bromo/amino groups enable post-polymerization functionalization.
- Coordination Chemistry: Acts as a bidentate ligand (N/O donors) for metal complex synthesis; complexes studied for catalytic and photoluminescent properties.
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Safety Information
- Hazard Symbols: GHS07 (Irritant)
- Signal Word: Warning
- Hazard Statements: H315 (Skin irritation), H319 (Serious eye irritation), H335 (May cause respiratory irritation)
- Precautionary Statements: P261 (Avoid breathing dust), P280 (Wear protective gloves/eye protection), P305+P351+P338 (IF IN EYES: Rinse continuously with water for several minutes)
- UN Number: Not classified
- Handling: Use in fume hood; avoid inhalation/skin/eye contact; wash hands thoroughly after handling
