2-Bromo-5-(trifluoromethyl)pyridine is a high-value fluorinated halogenated pyridine building block. The bromine atom at pyridine ring can undergo Suzuki coupling, Heck reaction, Sonogashira reaction and Buchwald-Hartwig amination for structural derivatization. The trifluoromethyl group can improve lipophilicity, chemical stability and metabolic stability of bioactive molecules. It is widely used as key intermediate for synthesis of kinase inhibitors, anticancer drugs, anti-inflammatory agents and central nervous system drugs. It is also commonly used in medicinal chemistry compound library construction, structure-activity relationship research and agrochemical intermediate development.