1. Molecular Formula

C19H20Br2N6O4S

2. Molecular Weight

588.27

3. Physical Properties

Macitentan appears as white to off-white crystalline powder. It has extremely low solubility in pure water, freely soluble in DMSO, slightly soluble in anhydrous ethanol. Its melting point ranges from 103°C to 107°C. Under sealed room temperature environment, it maintains stable physical form. This product is photosensitive; prolonged exposure to strong light will lead to color darkening and partial quality decline. It has no volatile property at normal temperature.

4. Chemical Properties

It is an organic sulfonamide derivative compound. It shows stable chemical property under dry, room-temperature and sealed storage. It is incompatible with strong oxidants, concentrated strong acids and strong alkalis. When exposed to high temperature above 120°C, thermal decomposition will happen and release toxic bromide-containing fumes. It cannot be mixed and stored with reducing agents. No obvious chemical reaction occurs under normal storage environment without contacting corrosive substances.

5. Storage Condition

Seal the product completely and store it in cool, dry and dark warehouse. Control storage temperature below 25°C, keep away from direct sunlight, heat sources and humid air. Isolate the goods from oxidants, strong acids and strong alkalis during storage. The valid shelf life is 24 months if stored as required.

6. Usage

Macitentan is high-purity pharmaceutical API and dual endothelin receptor antagonist. It is mainly applied for clinical drug raw material of pulmonary arterial hypertension (PAH). It can block ET-A and ET-B receptors, decrease pulmonary vascular resistance and pulmonary arterial pressure, improve patients' exercise endurance and cut down the risk of PAH relevant hospitalization. Besides mass pharmaceutical formulation production, it is also widely used in laboratory pharmacological research, new drug development and pharmaceutical intermediate testing experiments.

Separate Standard Table