4-Acetamidophenol
- Createtime： 2026-04-09
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
151.16
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4-Acetamidophenol
1. Basic Product Information
Product Name: 4-Acetamidophenol
CAS Number: 103-90-2
Molecular Formula: C8H9NO2
Molecular Weight: 151.16
Synonyms: Paracetamol, Acetaminophen, N-(4-hydroxyphenyl)acetamide
Product Category: Oral antipyretic analgesic API, controlled clinical pharmaceutical raw material, phenolic fine chemical intermediate
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White crystalline powder
- Odor: Odorless, slight bitter taste
- Solubility: Slightly soluble in cold water, soluble in hot water; soluble in ethanol, methanol; insoluble in ether, benzene and aliphatic alkanes
- Melting Point: 168–172 °C
- Density (20 °C): 1.29 g/cm3
- Hygroscopicity: Non-hygroscopic under sealed dry storage
- Aqueous Stability: Stable under neutral and weakly acidic aqueous systems; amide hydrolysis occurs under high temperature and strong alkaline conditions to generate p-aminophenol impurities
Chemical Characteristics
- Molecular Structure: Para-substituted phenolic acetamide, benzene ring with hydroxyl and acetamido dual functional groups
- Core Functional Mechanism: Non-steroidal antipyretic analgesic; inhibits central prostaglandin synthesis to relieve fever and mild pain; no obvious anti-inflammatory effect at conventional dosage
- Photostability: Light-sensitive; long-term UV irradiation causes phenolic oxidation to turn brown
- Thermal Stability: Stable below 120 °C; heating above 150 °C accelerates amide bond degradation
- Chemical Compatibility: Compatible with neutral polar solvents and common pharmaceutical excipients; incompatible with strong oxidants, concentrated strong alkalis and heavy metal ions
3. Main Application Fields
- Core Application: Over-the-counter Antipyretic Analgesic API
Raw material for tablets, granules, oral suspensions and injection formulations for fever, headache, joint pain and toothache relief - Compound Pharmaceutical Preparation Raw Material
Formula component of cold compound medicines combined with antihistamine and cough-suppressant ingredients - Synthetic Intermediate
Starting material for manufacturing pharmaceutical derivatives and organic dye intermediates - Biochemical Research Reagent
Standard substrate for phenol oxidase enzyme activity detection experiments
4. Platform Category & Product Group Guidance
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical APIs
Reason: Global mass-produced prescription & OTC clinical antipyretic pharmaceutical raw material
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do NOT classify as general industrial chemicals; it is regulated human oral pharmaceutical API
3. Standard Foreign Trade Packaging Specification
1g / 5g nitrogen-sealed amber glass vials for reference standards; 1kg aluminum foil vacuum bags for pilot batches; 25kg double PE-lined lightproof fiber drums for GMP bulk production
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 103-90-2 |
| Molecular Formula | C8H9NO2 |
| Appearance | Uniform white crystalline powder without brown impurities |
| HPLC Purity | Pharma Grade ≥99.0%, Reference Standard ≥99.8% |
| Melting Point | 168–172 °C |
| Water Content (KF Method) | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Lightproof nitrogen-filled vacuum aluminum foil bag, cool dry warehouse storage |
