1-([4-Amino-2-propyl-5-pyrimidinyl]methyl)-2-methylpyridinium chloride
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
278.78
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1-[(4-Amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridinium chloride
1. Basic Product Information
Product Name: 1-[(4-Amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridinium chloride
CAS Number: 137-88-2
Molecular Formula: C14H19ClN4
Molecular Weight: 278.78
Synonyms: Thiamine chloride analog, Pyrithiamine chloride, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride
Product Category: Biochemical research reagent, vitamin antagonist, pharmaceutical intermediate, enzyme inhibitor raw material
2. Physical and Chemical Properties
Physical Indicators
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, methanol; soluble in ethanol; slightly soluble in acetone; insoluble in chloroform, alkanes
- Melting Point: 248–252 °C (decomposes)
- Density (20 °C): 1.18 g/cm3
- Hygroscopicity: Moderately hygroscopic, absorbs moisture in humid air
- Aqueous Stability: Stable under weak acidic aqueous conditions; decomposes slowly under alkaline and high temperature conditions
Chemical Characteristics
- Molecular Structure: Cationic heterocyclic salt composed of aminopyrimidine side chain and methylpyridinium, paired with chloride anion
- Core Biological Function: Thiamine (vitamin B1) competitive antagonist, inhibits thiamine-dependent enzyme activity in cells
- Hydrolysis Tendency: Pyridinium methyl linkage is susceptible to cleavage under strong alkaline heating
- Photostability: Light-sensitive; long-term light exposure causes discoloration and reduced biological activity
- Thermal Stability: Stable below 100 °C; irreversible thermal decomposition above 240 °C, releasing irritating nitrogen-containing heterocyclic fumes
- Chemical Compatibility: Compatible with weak acidic aqueous buffers; incompatible with strong alkalis, strong oxidants, heavy metal ions
3. Main Application Fields
- Core Application: Biochemical Laboratory Research Reagent
Classic thiamine antagonist for cell metabolism, neurobiology and microbial culture research; used to induce vitamin B1 deficiency models - Pharmaceutical Synthetic Intermediate
Raw material for anti-protozoal and anti-parasitic drug screening compounds - Pharmacology Reference Standard
Control substance for HPLC detection of thiamine analog impurities in vitamin formulations - Microbial Culture Additive
Selective inhibitor for thiamine-dependent strains in microbial screening experiments
4. Platform Category & Product Group Selection Guide
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: It is a bioactive heterocyclic salt for pharmaceutical and biochemical research, classified as pharmaceutical intermediate.
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do not select Basic Organic Chemicals; this product is mainly used for pharmaceutical and biochemical research, matching pharmaceutical chemical grouping.
3. Standard Foreign Trade Packaging Specification
1g/5g glass vial with nitrogen seal for lab samples; 25kg fiber drum lined with double PE inner bags for bulk orders; customized sterile packaging available
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 137-88-2 |
| Molecular Formula | C14H19ClN4 |
| Appearance | Uniform white crystalline powder without yellow discoloration |
| HPLC Purity | Biochemical Grade ≥99.0%, Reference Standard ≥99.8% |
| Water Content (KF Method) | ≤0.40% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Light-proof nitrogen-sealed aluminum foil vacuum bag, low-temperature sealed container |
