2-Chloro-5-nitropyridine
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
158.54
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Light yellow crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Chloro-5-nitropyridine
1. Basic Product Information
Product Name: 2-Chloro-5-nitropyridine
CAS Number: 4548-45-2
Molecular Formula: C5H3ClN2O2
Molecular Weight: 158.54
Synonyms: 2-Chloro-5-nitro pyridine
Product Category: Halogenated pyridine fine chemical, pharmaceutical heterocyclic intermediate, organic synthesis raw material
2. Physical and Chemical Properties
Physical Indicators
- Appearance: Light yellow crystalline powder
- Odor: Slight heterocyclic aromatic odor
- Solubility: Soluble in dichloromethane, DMF, THF, hot ethanol; slightly soluble in methanol; insoluble in cold water and petroleum ether
- Melting Point: 106–110 °C
- Density (20 °C): 1.47 g/cm3
- Hygroscopicity: Non-hygroscopic under sealed dry storage
- Aqueous Stability: Stable in neutral cold water, slowly hydrolyzed under strong alkaline heating
Chemical Characteristics
- Molecular Structure: Pyridine ring with chlorine at C2 and nitro group at C5; contains active aryl chloride and nitro functional groups
- Aryl Chloride Reactivity: Undergoes nucleophilic substitution, Suzuki coupling, Buchwald amination to construct pyridine-based drug skeletons
- Nitro Group Modification: Can be reduced to amino group for further derivatization into amides, ureas, heterocycles
- Photostability: Slightly light-sensitive; long-term UV exposure produces trace dechlorination impurities and darkens
- Thermal Stability: Stable below 100 °C; decomposes above melting point to release irritating hydrogen chloride and nitrogen oxide fumes
- Chemical Compatibility: Compatible with anhydrous polar aprotic solvents; incompatible with strong alkali, reducing agents and strong oxidants
3. Main Application Fields
- Core Application: Pharmaceutical Heterocyclic Intermediate
Key building block for anti-inflammatory, anti-tumor, antibacterial and central nervous system APIs; widely used to synthesize pyridine-containing small molecule drugs via substitution and reduction reactions - Pesticide & Herbicide Raw Material
Precursor for high-efficiency pyridine fungicides and insecticides with broad-spectrum crop protection activity - Laboratory Organic Synthesis Reagent
Standard substrate for cross-coupling, nucleophilic substitution and pyridine ring functionalization research - Organic Dye & Photosensitizer Precursor
Raw material for high-performance pyridine-based azo dyes and photochemical sensitizers
4. Platform Category & Product Group Selection Guide
1) Domestic B2B Platform Category
Recommended Path: Organic Intermediates / Pharmaceutical Intermediates
Reason: It is a core heterocyclic intermediate for human pharmaceutical synthesis, classified as pharmaceutical intermediate.
2) English Product Group Dropdown Options
Recommended Selection: Pharmaceutical Chemicals
Do not select Basic Organic Chemicals; this product is mainly supplied for pharmaceutical API production, matching pharmaceutical chemical grouping.
3. Standard Foreign Trade Packaging Specification
1kg aluminum foil vacuum bag for lab samples; 25kg fiber drum lined with double PE inner bags for bulk industrial orders; customized packaging specifications are available upon request
5. Quality Specification Table
| Test Item | Standard Requirement |
| CAS Number | 4548-45-2 |
| Molecular Formula | C5H3ClN2O2 |
| Appearance | Uniform light yellow crystalline powder without dark brown impurities |
| HPLC Purity | Pharma Intermediate Grade ≥99.0%, Industrial Grade ≥98.5% |
| Melting Point | 106–110 °C |
| Water Content (KF Method) | ≤0.20% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Standard Storage Package | Light-proof nitrogen-sealed aluminum foil vacuum bag, 25kg PE lined fiber drum |
