2-BROMO-1-PHENYL-PENTAN-1-ONE
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
liquid
|
| Molecular Weight |
241.12
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Pale yellow transparent oily liquid
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-Bromo-1-phenylpentan-1-one
1. Basic Information
Name: 2-Bromo-1-phenylpentan-1-one
Alias: α-Bromo valerophenone, 2-Bromovalerophenone
CAS No.: 49851-31-2
Molecular Formula: C11H13BrO
Molecular Weight: 241.12
Category: α-Bromo ketone pharmaceutical intermediate, fine chemical alkylation reagent, organic synthesis substrate, photoinitiator raw material
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow transparent oily liquid
- Odor: Mild pungent aromatic ketone odor
- Solubility: Miscible with dichloromethane, chloroform, toluene, ethanol, acetone; slightly soluble in cold water
- Boiling Point: Decomposes above 260 °C under atmospheric pressure
- Density (20 °C): 1.325–1.332 g/cm3
- Refractive Index nD20: 1.538–1.543
- Flash Point: 112 °C
- Hygroscopy: Non-hygroscopic
- Aqueous property: Neutral α-bromo aromatic ketone, stable in neutral cold water at ambient temperature
Chemical Properties
- Molecular structure: Aromatic ketone with bromine substitution at the α-carbon adjacent to carbonyl group; highly reactive α-bromo carbonyl skeleton
- Alkylation reactivity: The α-bromine atom undergoes SN2 nucleophilic substitution with amines, thiols, alcohols and enolates to construct various drug side chains
- Elimination reaction: Under alkaline conditions, dehydrobromination occurs to form α,β-unsaturated ketone derivatives
- Photostability: Strongly light-sensitive; long-term UV exposure accelerates de-bromination and darkens liquid color
- Thermal stability: Stable below 140 °C; prolonged high-temperature heating releases irritating bromine-containing fumes
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with strong oxidants, concentrated alkaline solutions and primary/secondary amines under heating
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key building block for synthesizing antidepressants, anti-inflammatory and cardiovascular small-molecule APIs via α-substitution cyclization
2. Organic Synthesis Laboratory Reagent
Standard α-halo ketone substrate for nucleophilic substitution, cyclization and heterocycle formation research
3. UV Photoinitiator Precursor
Raw material for synthesizing α-amino ketone type photoinitiators used in UV curing coatings and inks
4. Agrochemical Intermediate
Precursor for brominated ketone fungicides and plant growth regulators
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 49851-31-2 |
| Molecular Formula | C11H13BrO |
| Appearance | Pale yellow clear oily liquid without suspended solids |
| GC Purity | Synthetic Grade ≥98.5%, High-Purity Reagent Grade ≥99.0% |
| Water Content (KF) | ≤0.10% |
| Chroma (APHA) | ≤120 |
| Free Bromide Ion | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Amber light-proof sealed glass bottle; bulk 200kg lined iron drum filled with nitrogen |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 °C, full light shielding, isolated from alkaline materials and oxidants |
| Transportation Requirement | Light-sensitive brominated ketone liquid, standard sealed packaging, separated from corrosive hazardous goods |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
