4,5-Dicyanoimidazole
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
118.09
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4,5-Dicyanoimidazole
1. Basic Information
Name: 4,5-Dicyanoimidazole
Alias: DCI, 1H-Imidazole-4,5-dicarbonitrile
CAS No.: 1122-28-7
Molecular Formula: C5H2N4
Molecular Weight: 118.09
Category: Nucleic acid synthesis activator, heterocyclic pharmaceutical intermediate, organic synthetic catalyst, electronic chemical reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Soluble in DMF, DMSO, acetonitrile, hot methanol; slightly soluble in ethanol; almost insoluble in cold water, ethers and aliphatic hydrocarbons
- Melting Point: 168–172 °C (decomposes)
- Predicted Density: 1.38 g/cm3
- Hygroscopy: Moderately hygroscopic, easy to agglomerate under high humidity
- Aqueous property: Weakly acidic nitrogen heterocycle; stable in neutral cold water; cyano groups hydrolyze under strong acid/alkali heating
Chemical Properties
- Molecular structure: Imidazole ring disubstituted with cyano groups at C4 and C5 positions, contains active NH proton and two electrophilic cyano functional groups
- Catalytic activity: Powerful activator for phosphoramidite coupling in oligonucleotide DNA/RNA synthesis, accelerates phosphite triester formation
- Functional group reactivity: Cyano groups can be hydrolyzed to carboxylic acids, reduced to amines, or cyclized to construct fused nitrogen heterocycles; ring NH undergoes alkylation and acylation
- Photostability: Slightly light-sensitive; long-term UV exposure generates minor oxidative impurities
- Thermal stability: Stable below 150 °C; above melting point, thermal decomposition releases toxic cyanide fumes
- Compatibility: Compatible with anhydrous polar aprotic solvents used in nucleic acid synthesis; incompatible with strong oxidants, concentrated strong acid and alkaline solutions under heating
3. Main Application Fields
1. Oligonucleotide Synthesis Activator (Core Application)
Industry-standard coupling catalyst for solid-phase synthesis of DNA, RNA and modified nucleic acid raw materials
2. Pharmaceutical Heterocyclic Intermediate
Precursor for synthesizing imidazole-based anti-viral, anti-inflammatory and anti-tumor small-molecule APIs
3. Organic Synthetic Base Catalyst
Mild nitrogen heterocyclic catalyst for esterification, condensation and cyclization reactions
4. Electronic Chemical Additive
Component for semiconductor photoresist and high-purity electronic grade reagent formulations
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 1122-28-7 |
| Molecular Formula | C5H2N4 |
| Appearance | Uniform white crystalline powder without discoloration |
| HPLC Purity | Nucleic Acid Grade ≥99.5%, Synthetic Grade ≥99.0% |
| Melting Point | 168–172 °C (decomposed) |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.05% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤5 ppm |
| Packaging | Light-proof nitrogen-filled aluminum foil vacuum bag; bulk 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse at 2–25 °C, full light shielding, isolated from humid air and oxidants |
| Transportation Requirement | Hygroscopic light-sensitive heterocyclic powder, moisture-proof sealed packaging, separated from corrosive hazardous goods |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
