5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
158.54
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Uniform white crystal
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
5-Chloro-pyrazine-2-carboxylic acid
1. Basic Information
Name: 5-Chloro-pyrazine-2-carboxylic acid
Alias: 5-Chloro-2-pyrazinecarboxylic acid
CAS No.: 36070-80-1
Molecular Formula: C5H3ClN2O2
Molecular Weight: 158.54
Category: Chloropyrazine heterocyclic intermediate, pharmaceutical API building block, agrochemical bactericide raw material
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Faint mild heterocyclic sour odor
- Solubility: Soluble in hot ethanol, methanol, DMF, dilute alkaline water; slightly soluble in cold water; insoluble in toluene, hexane, ethyl acetate
- Melting Point: 182–186 ℃ (decomposes)
- Density (predicted): 1.47 g/cm3
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous property: Weakly acidic solid; reacts with alkali to generate soluble carboxylate salts; stable at room temperature neutral water
Chemical Properties
- Molecular structure: Pyrazine six-membered nitrogen heterocycle, C5 chlorine substitution, C2 carboxylic acid group; dual reactive sites of aryl chloride and carboxyl
- Carboxyl derivatization: Carboxylic acid can undergo esterification, amidation, acid chloride synthesis to construct drug side chains
- Aryl chloride nucleophilic substitution: C5 Cl participates SNAr reaction with amines, alcohols, thiols to introduce functional substituents
- Thermal stability: Stable below 150 ℃; above melting point decarboxylation occurs to form 2-chloropyrazine impurity
- Photostability: Slightly light-sensitive; long-term UV irradiation turns powder pale yellow
- Compatibility: Compatible with polar aprotic solvents, weak alkaline aqueous solution; incompatible with strong oxidants, concentrated strong acid under high temperature
3. Main Application Fields
1. Pharmaceutical Heterocyclic Intermediate (Core Application)
Core fragment for anti-tumor, anti-bacterial, metabolic disease small molecule APIs; used for synthesizing pyrazine-series targeted therapeutic drugs
2. Agricultural Pesticide Intermediate
Raw material for broad-spectrum pyrazine fungicides, crop disease prevention agents
3. Organic Synthesis Lab Reagent
Standard substrate for aromatic nucleophilic substitution and carboxylic acid functional transformation research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 36070-80-1 |
| Molecular Formula | C5H3ClN2O2 |
| Appearance | Uniform white crystal without yellow discoloration |
| HPLC Purity | Synthetic Intermediate Grade ≥98.5% |
| Melting Point | 182–186 ℃ |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 100g/1kg amber light-proof aluminum foil vacuum bag, 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, light shielding, isolate strong oxidants and high temperature heat sources |
| Transportation Requirement | Slightly light-sensitive chloropyrazine crystal, conventional moisture-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Mild irritant chlorinated heterocyclic acidic powder. Dust irritates eyes, nasal and respiratory mucosa; long-term skin contact may cause slight allergic itching. All operations in ventilated fume hood with dust mask, splash-proof goggles and chemical-resistant nitrile gloves. Avoid long-time high temperature heating to prevent decarboxylation decomposition. Waste liquid neutralized with dilute alkali before discharge; solid waste classified as halogen-containing organic hazardous waste for professional disposal.
