Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
2-bromo-3-methylpropiophenone
1. Basic Information
Name: 2-bromo-3-methylpropiophenone
Alias: 2-Bromo-1-phenyl-3-methylbutan-1-one
CAS No.: 1451-83-8
Molecular Formula: C10H11BrO
Molecular Weight: 227.10
Category: α-Bromo aliphatic aromatic ketone fine chemical intermediate, pharmaceutical synthetic building block, cross-coupling reaction substrate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow transparent oily liquid
- Odor: Pungent halogenated ketone irritating smell
- Solubility: Soluble in DCM, chloroform, THF, DMF, toluene, ethanol; insoluble in water, hexane, petroleum ether
- Boiling Point: Decomposes at high temperature under normal pressure, vacuum distillable
- Density (20℃): 1.32–1.36 g/cm3
- Refractive Index n?2?: 1.545–1.555
- Hygroscopy: Non-hygroscopic
- Aqueous property: Neutral liquid, stable in neutral water at room temperature; hydrolyzes slowly under strong acid/alkali heating
Chemical Properties
- Molecular structure: Phenyl ketone parent, α-position active bromine atom, isobutyl side chain; active α-bromo is the core reactive site
- SN2 nucleophilic substitution: α-bromo easily reacts with amines, thiols, alcohols to construct heterocyclic skeletons for antibacterial and anti-inflammatory drugs
- Carbonyl characteristic reactions: Ketone group undergoes condensation, reduction, cyclization to generate five-membered nitrogen heterocyclic intermediates
- Debromination risk: Strong reducing agents remove bromine atom to form alkyl ketone impurities
- Photolysis characteristic: Strongly light-sensitive; UV light breaks C-Br bond, releases bromine free radicals, liquid darkens
- Thermal stability: Stable below 100 ℃; long-time heating above 120 ℃ produces decomposition impurities
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with strong reducing agents, concentrated alkali, strong oxidants, active metals
3. Main Application Fields
1. Pharmaceutical Heterocyclic Intermediate (Core Application)
Key raw material for synthesis of small-molecule antibacterial, anti-inflammatory APIs; α-bromo site for ring closure reaction to form nitrogen/sulfur heterocyclic drug skeletons
2. Organic Synthesis Research Reagent
Difunctional substrate containing carbonyl and active bromine for multi-step synthetic methodology research
3. Dye & Fine Fragrance Intermediate
Precursor for synthesis of halogen-substituted aromatic ketone derivatives with special chromogenic and aromatic properties
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 1451-83-8 |
| Molecular Formula | C10H11BrO |
| Appearance | Pale yellow clear oily liquid without precipitate |
| GC Purity | Synthetic Intermediate Grade ≥98.0% |
| Water Content (KF) | ≤0.15% |
| Chroma (APHA) | ≤150 |
| Free Bromide Ion | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber light-proof glass bottle; bulk 200kg nitrogen-sealed galvanized iron drum |
| Storage Condition | Hermetically sealed cool dark warehouse below 25 ℃, full light shielding, isolate reducing agents and alkaline chemicals |
| Transportation Requirement | Highly light-sensitive corrosive bromoketone liquid, sealed light-proof packaging, separated from food, oxidants and acid chemicals |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Highly irritating toxic brominated ketone liquid. Vapor severely irritates eyes, nasal cavity, throat and respiratory tract; skin contact causes corrosive redness, burning and blistering. Contact with strong alkali releases irritating bromide fumes. All operations must be carried out in fully ventilated fume hood with gas-proof respirator, UV-blocking splash-proof goggles and thick oil-resistant nitrile gloves. Strictly avoid light exposure, high temperature, open flame and mixing with reducing agents/alkali. Waste liquid treated with sodium thiosulfate reduction + neutralization before discharge; waste classified as halogen-containing toxic organic hazardous waste, handled by qualified licensed institutions.
