4-Nitro-2,3-lutidine-N-oxide
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
168.15
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Uniform pale yellow crystal power
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4-Nitro-2,3-lutidine-N-oxide
1. Basic Information
Name: 4-Nitro-2,3-lutidine-N-oxide
Alias: 2,3-Dimethyl-4-nitropyridine N-oxide
CAS No.: 37699-43-7
Molecular Formula: C7H8N2O3
Molecular Weight: 168.15
Category: Pyridine N-oxide heterocyclic intermediate, pharmaceutical synthetic building block, pesticide raw material, aromatic substitution reaction substrate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder
- Odor: Faint mild heterocyclic odor
- Solubility: Soluble in DCM, chloroform, DMF, DMSO, hot ethanol; slightly soluble in cold methanol; insoluble in water, hexane, petroleum ether
- Melting Point: 92–96 ℃
- Density (predicted): 1.29 g/cm3
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous property: Neutral solid, stable in neutral water at room temperature; no hydrolysis under normal conditions
Chemical Properties
- Molecular structure: Pyridine ring with 2,3-dimethyl, 4-nitro substitution, pyridine nitrogen oxidized to N-oxide; N-oxide group activates ortho/para positions for nucleophilic substitution
- Regioselective halogenation/reduction: N-oxide directing group enables selective reduction of nitro group or deoxygenation of N-oxide to construct substituted pyridine APIs
- Nitro group derivatization: Nitro can be reduced to amino, diazotized, acylated to introduce multiple functional fragments
- N-oxide deoxygenation: React with phosphorus trichloride, iron powder to remove oxygen atom and get 4-nitro-2,3-lutidine
- Thermal stability: Stable below 85 ℃; long-term heating above melting point has risk of slight decomposition
- Photostability: Slightly light-sensitive; long-term UV irradiation turns deep yellow
- Compatibility: Compatible with anhydrous polar aprotic solvents; incompatible with strong reducing agents, concentrated strong alkali, concentrated acid at high temperature
3. Main Application Fields
1. Pharmaceutical Pyridine Intermediate (Core Application)
Precursor for synthesizing substituted aminopyridine series drugs; used to prepare digestive system, anti-inflammatory and antibacterial small-molecule APIs
2. Agricultural Chemical Intermediate
Raw material for pyridine-based fungicides, insecticides and plant growth regulators
3. Organic Synthesis Research Reagent
Classic pyridine N-oxide substrate for studying aromatic nucleophilic substitution, nitro reduction and deoxygenation reactions
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 37699-43-7 |
| Molecular Formula | C7H8N2O3 |
| Appearance | Uniform pale yellow crystal without brown impurities |
| HPLC Purity | Synthetic Intermediate Grade ≥98.0% |
| Melting Point | 92–96 ℃ |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.15% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 100g/1kg amber light-proof aluminum foil vacuum bag, 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, light shielding, isolate strong reducing agents and alkaline raw materials |
| Transportation Requirement | Slightly light-sensitive nitro pyridine crystal, conventional moisture-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Irritant nitro heterocyclic crystalline powder. Dust irritates eyes, nasal and respiratory mucosa; long-term skin contact may cause mild allergic itching. Avoid mixing with strong reducing agents to prevent exothermic reaction. All operations in ventilated fume hood with dust mask, splash-proof goggles and chemical-resistant nitrile gloves. Waste liquid diluted and treated before discharge; solid waste classified as nitro-containing organic hazardous waste for professional disposal.
