Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Nicotinamide riboside chloride
1. Basic Information
Name: Nicotinamide riboside chloride
Alias: NR-Cl, Nicotinamide β-D-riboside chloride
CAS No.: 23111-00-4
Molecular Formula: C??H??ClN?O?
Molecular Weight: 290.70
Category: NAD+ precursor nutritional raw material, health food additive, anti-aging cosmetic raw material, cell culture medium supplement, biochemistry research reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless, slight mild bitter taste
- Solubility: Freely soluble in water; soluble in methanol; slightly soluble in ethanol; insoluble in acetone, ethyl acetate, petroleum ether
- Melting Point: Decomposes above 140 ℃ without distinct melting point
- Density (predicted): 1.42 g/cm3
- Hygroscopy: Moderately hygroscopic, easy to absorb moisture and agglomerate under high humidity
- Aqueous property: Weakly acidic aqueous solution, pH 3.5–5.0; prone to hydrolysis under high temperature and strong alkaline conditions
Chemical Properties
- Molecular structure: Nicotinamide linked to β-D-ribose via glycosidic bond, chloride ion as counterion; pyridine nitrogen positively charged, core precursor of intracellular NAD+, NADP+, NADH
- Glycosidic bond hydrolysis: High temperature, strong acid or strong alkali breaks riboside bond to generate nicotinamide and ribose, losing biological activity
- Light oxidation sensitivity: Pyridine ring is easily oxidized under UV light to form yellow degradation impurities, activity decreases sharply
- Thermal stability: Stable below 60 ℃; long-term heating above 80 ℃ accelerates hydrolysis and discoloration
- Metal ion catalyzed degradation: Heavy metal ions (Cu2?, Fe3?) accelerate oxidative decomposition
- Photostability: Extremely light-sensitive; must be stored away from light
- Compatibility: Compatible with neutral and weakly acidic carriers, trehalose, vitamin series; incompatible with strong alkali, strong oxidants, heavy metal salts
3. Main Application Fields
1. Functional Health Food Raw Material (Core Application)
NAD+ boosting ingredient; supports mitochondrial energy metabolism, anti-fatigue, anti-aging, improves sleep quality, maintains skin and nerve health; used in oral capsules, powders, drinks
2. High-End Cosmetic Active Ingredient
Skin anti-aging raw material, repairs skin barrier, reduces fine lines, brightens dull complexion, added to essence, facial cream, mask
3. Cell & Microbial Culture Medium
NAD+ supplement for mammalian cell culture, yeast fermentation to improve cell viability and proliferation efficiency
4. Biochemical Laboratory Reagent
Positive control for NAD+ metabolism research, enzyme activity detection substrate for redox-related experiments
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 23111-00-4 |
| Molecular Formula | C??H??ClN?O? |
| Appearance | Uniform white crystal powder without yellow discoloration |
| HPLC Purity | Health Food Grade ≥99.0%, Reagent Grade ≥99.5% |
| Water Content (KF) | ≤2.00% |
| Residue on Ignition | ≤0.50% |
| Single Degradation Impurity | ≤0.20% |
| Total Related Substances | ≤1.00% |
| Heavy Metals (Pb) | ≤5 ppm |
| Microbial Limit | Total bacteria ≤100 CFU/g, no pathogenic bacteria |
| Packaging | Amber light-proof nitrogen-filled aluminum foil vacuum bag; bulk 1kg/5kg PE lined light-proof fiber drum |
| Storage Condition | Hermetically sealed cool warehouse 2–25 ℃, full light shielding, isolate humid air, alkali and heavy metal raw materials |
| Transportation Requirement | Highly light-sensitive hygroscopic nucleoside raw material, sealed moisture-proof light-blocking packaging, avoid high temperature and sunlight |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Mild irritant nucleoside powder. Dust inhalation irritates nasal and respiratory mucosa; direct eye contact causes slight stinging discomfort. All operations carried out in light-proof ventilated fume hood with dust mask, UV-blocking goggles and nitrile gloves. Strictly avoid light exposure, high temperature and contact with alkaline substances. Waste liquid diluted and neutralized before discharge; solid waste belongs to general biochemical nutritional raw material waste. Safe oral intake within specified dosage, no acute toxicity.
