4-Acetylbiphenyl
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
solid
|
| Molecular Weight |
196.24
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White to off-white crystalline solid
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4-Acetylbiphenyl
1. Basic Information
Name: 4-Acetylbiphenyl
Alias: 4-Biphenyl methyl ketone, 4-Acetyl diphenyl
CAS No.: 92-91-1
Molecular Formula: C??H??O
Molecular Weight: 196.24
Category: Aromatic ketone fine chemical intermediate, liquid crystal monomer raw material, pharmaceutical synthetic building block, UV absorbent precursor
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline solid
- Odor: Faint aromatic ketone odor
- Solubility: Soluble in dichloromethane, chloroform, THF, DMF, hot ethanol, toluene; slightly soluble in cold methanol; insoluble in water, hexane, petroleum ether
- Melting Point: 116–118 ℃
- Boiling Point: 325–330 ℃
- Density (predicted): 1.08 g/cm3
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Aqueous property: Neutral solid, stable in neutral water; no hydrolysis at room temperature
Chemical Properties
- Molecular structure: Biphenyl parent skeleton with acetyl group at para position, contains conjugated aromatic ring and ketone carbonyl
- Carbonyl characteristic reactions: Aldol condensation, imine formation, reduction to secondary alcohol, Wolff-Kishner reduction to alkyl biphenyl; used to construct liquid crystal side chains
- Aromatic ring modification: Biphenyl ring undergoes halogenation, nitration, sulfonation to introduce functional groups for UV absorber and pharmaceutical intermediates
- Cross-coupling substrate: Ketone can be converted to halide derivatives for Suzuki, Heck coupling reactions
- Thermal stability: Stable below 110 ℃; long-term heating above melting point leads to slight oxidation and yellowing
- Photostability: Slightly light-sensitive; long-term UV irradiation gradually turns pale yellow
- Compatibility: Compatible with common organic solvents; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Liquid Crystal Material Intermediate (Core Application)
Key raw material for synthesizing biphenyl liquid crystal monomers; the acetyl group is derivatized to form alkyl, ester, cyano liquid crystal functional fragments
2. Pharmaceutical Synthetic Intermediate
Building block for anti-inflammatory, anti-tumor small molecule drugs with biphenyl core structure
3. UV Absorber & Light Stabilizer Precursor
Used to synthesize benzophenone series UV absorbers for plastics, coatings, cosmetics
4. Organic Synthesis Laboratory Reagent
Standard conjugated aromatic ketone substrate for carbonyl reduction, aromatic derivatization research
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 92-91-1 |
| Molecular Formula | C??H??O |
| Appearance | Uniform white crystal without yellow impurities |
| HPLC Purity | Liquid Crystal Grade ≥99.5%, Industrial Grade ≥98.0% |
| Melting Point | 116–118 ℃ |
| Water Content (KF) | ≤0.10% |
| Residue on Ignition | ≤0.05% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 10g/100g light-proof aluminum foil vacuum bag, 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, light shielding, isolate oxidants and strong alkali |
| Transportation Requirement | Slightly light-sensitive aromatic ketone crystal, conventional moisture-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Mild irritant biphenyl ketone crystalline powder. Dust irritates eyes, nasal and respiratory mucosa; prolonged skin contact may cause mild dry allergic itching. All operations in ventilated fume hood with dust mask, splash-proof goggles and chemical-resistant nitrile gloves. Avoid mixing with strong oxidants to prevent oxidative discoloration. Waste liquid diluted and treated before discharge; solid waste belongs to general aromatic organic hazardous waste for professional disposal.
