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Acetamide, 2-[[bis(4-fluorophenyl)methyl]sulfinyl]-N-hydroxy-
1. Basic Information
Name: 2-[[Bis(4-fluorophenyl)methyl]sulfinyl]-N-hydroxyacetamide
Alias: Fladrafinil, CRL-40,941, Bisfluoroadrafinil, Difluoroadrafinil
CAS No.: 90212-80-9
Molecular Formula: C15H13F2NO3S
Molecular Weight: 325.33
Category: Fluorinated brain health pharmaceutical raw material, nootropic drug candidate, neuropharmacology research reagent, fine fluorinated pharmaceutical intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Uniform white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water; soluble in methanol, ethanol, DMSO, DMF, acetonitrile; insoluble in alkanes, petroleum ether
- Melting Point: 194–202 ℃
- Density (predicted): 1.50 ± 0.10 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Weakly acidic aqueous suspension, stable at pH 4–8
Chemical Properties
- Molecular structure: Contains bis(4-fluorophenyl)methyl group, sulfinyl (-SO-) linkage, N-hydroxyacetamide functional group; fluorinated aromatic skeleton improves metabolic stability
- Hydroxamic acid reactivity: N-hydroxy amide group can form chelate complexes with metal ions, participates in enzyme inhibition research
- Sulfoxide characteristic: Sulfinyl group can be reduced to sulfide or oxidized to sulfone under redox conditions
- Thermal stability: Stable below 160 ℃; prolonged heating above melting point triggers partial decomposition and discoloration
- Photostability: Light-sensitive, long-term UV irradiation turns pale yellow
- Compatibility: Compatible with polar aprotic solvents and weak neutral medium; incompatible with strong oxidants, concentrated strong alkali, strong reducing agents
3. Main Application Fields
1. Nootropic Neuropharmacology Research Raw Material (Core Application)
Novel wakefulness-promoting cognitive-enhancing candidate compound; used for laboratory brain function, fatigue resistance, mental alertness pharmacological study
2. Fluorinated Pharmaceutical Intermediate
Synthetic precursor for central nervous system therapeutic derivatives, hydroxamic acid class enzyme inhibitor building block
3. Biochemical Research Reagent
Substrate for dopamine receptor, monoamine oxidase related in-vitro pharmacology experiments
4. Laboratory Reference Standard
HPLC reference standard for adrafinil series fluorinated cognitive compound detection
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 90212-80-9 |
| Molecular Formula | C15H13F2NO3S |
| Appearance | Uniform white crystal powder without yellow oxidized impurities |
| HPLC Purity | Research Grade ≥98.0%; Premium Lab Grade ≥99.0% |
| Melting Point | 194–202 ℃ |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 10g/100g/1kg vacuum aluminum foil bag, 25kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse 2–8 ℃, full light shielding, isolate oxidants and alkaline substances |
| Transportation Requirement | Light-sensitive fluorinated pharmaceutical powder, moisture-proof & light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed low-temperature storage |
Safety Warning
Low-toxic irritant fluorinated aromatic crystalline powder. Dust irritates eyes, nasal tract and respiratory mucosa; long-term skin contact may trigger mild dry itching. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile chemical-resistant gloves. Strictly for laboratory research use only, not approved oral human medicine raw material; improper intake may cause nervous system side effects. Waste liquid neutralized before discharge; solid waste classified as fluorine-containing pharmaceutical hazardous waste disposed by licensed professional institutions.
