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8-Hydroxyquinoline sulfate
1. Basic Information
Name: 8-Hydroxyquinoline sulfate
Alias: 8-Quinolinol sulfate, Bis(8-hydroxyquinolinium) sulfate
CAS No.: 134-31-6
Molecular Formula: (C9H7NO)2·H2SO4 = C18H16N2O6S
Molecular Weight: 388.39
Category: Metal chelating analytical reagent, broad-spectrum bactericide, pharmaceutical raw material, industrial corrosion inhibitor
2. Physical and Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder
- Odor: Slight quinoline characteristic odor
- Solubility: Soluble in water, dilute acid; slightly soluble in ethanol, methanol; insoluble in acetone, benzene, ether, aliphatic hydrocarbons
- Melting Point: Decomposes above 170 ℃
- Density (predicted): 1.45 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Acidic aqueous solution; dissociates into 8-hydroxyquinolinium cation and sulfate anion, strong metal chelating capacity
Chemical Properties
- Molecular structure: Double molecule of 8-hydroxyquinoline combined with sulfuric acid to form ionic salt; quinoline nitrogen and phenolic hydroxyl group form dual chelating sites
- Metal complexation: Selectively chelates Al3?, Fe3?, Cu2?, Zn2?, heavy metal ions to generate insoluble colored chelate precipitates, core principle of metal quantitative analysis
- Antibacterial activity: Releases 8-hydroxyquinoline in water to inhibit bacteria, fungi and mold growth
- pH sensitivity: Precipitates free 8-hydroxyquinoline when neutralized with alkali solution
- Thermal stability: Stable below 150 ℃; high temperature decomposes to release sulfur trioxide and quinoline volatile substances
- Photostability: Light-sensitive, long-term UV irradiation darkens powder and reduces chelation activity
- Compatibility: Compatible with acidic aqueous system; incompatible with strong alkali, strong oxidants, alkaline metal salts
3. Main Application Fields
1. Analytical Chemistry Reagent (Core Application)
Standard spectrophotometric precipitation reagent for qualitative and quantitative detection of aluminum, iron, copper and other heavy metal ions in water, food, ore samples
2. Industrial & Agricultural Biocide
Mold inhibitor for leather, textile, paper, coating; fungicide for crop seed treatment, prevents mildew rot
3. Pharmaceutical Raw Material
Antiseptic auxiliary for external dermatological preparations, raw material for intestinal anti-protozoan drugs
4. Metal Surface Treatment Additive
Corrosion inhibitor for aluminum alloy, steel cleaning liquid, removes trace heavy metal impurities in electroplating solution
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 134-31-6 |
| Molecular Formula | C18H16N2O6S |
| Appearance | Uniform pale yellow crystal without dark impurities |
| HPLC Purity | Analytical Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Free Sulfuric Acid | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Chelation Sensitivity | Qualified for Fe3? color reaction |
| Packaging | 10g/100g amber glass bottle, 1kg/5kg light-proof aluminum foil bag, 25kg PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate alkaline substances |
| Transportation Requirement | Light-sensitive acidic heterocyclic salt powder, moisture-proof sealed packaging |
| Shelf Life | 24 months under nitrogen vacuum sealed storage |
Safety Warning
Toxic irritant quinoline sulfate powder. Dust irritates eyes, nasal tract and respiratory tract; skin absorption may cause mild toxic reaction, avoid long-term contact. All operations must be carried out in ventilated fume hood with dust-proof respirator, splash-proof goggles and acid-resistant nitrile gloves. Avoid mixing with strong alkali to prevent precipitation and heat release. Waste liquid neutralized with soda ash before discharge; solid waste classified as toxic heterocyclic chemical hazardous waste disposed by licensed professional institutions.
