N-Acetyl-D-leucine
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
173.21
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
N-Acetyl-D-leucine
1. Basic Information
Name: N-Acetyl-D-leucine
Alias: Ac-D-Leu-OH, N-Acetyl-D-2-amino-4-methylpentanoic acid
CAS No.: 19764-30-8
Molecular Formula: C8H15NO3
Molecular Weight: 173.21
Category: Chiral amino acid derivative, peptide synthesis building block, biochemical research reagent, pharmaceutical chiral intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slight sour taste
- Solubility: Soluble in water, methanol, ethanol; slightly soluble in acetone; insoluble in ethyl acetate, petroleum ether, toluene
- Melting Point: 186–190 ℃
- Specific Rotation [α]???: ?18° ~ ?22° (c=2, methanol)
- Density (predicted): 1.13 g/cm3
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous property: Weakly acidic aqueous solution, stable at pH 4–9
Chemical Properties
- Molecular structure: D-type leucine protected by N-terminal acetyl group, contains carboxyl group and amide bond, chiral carbon center retains D configuration
- Carboxyl reactivity: Carboxylic acid can undergo esterification, amidation, condensation to form peptide bonds for peptide chain assembly
- Amide stability: Acetyl protecting group stable under neutral and weak acidic conditions; can be removed under strong acid heating to regenerate free D-leucine
- Chiral stability: No racemization under normal storage and mild reaction conditions
- Thermal stability: Stable below 160 ℃; prolonged heating above melting point causes partial decomposition
- Photostability: Slightly light-sensitive, long-term UV irradiation slowly turns pale yellow
- Compatibility: Compatible with aqueous buffer, low-carbon alcohols; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Peptide Synthesis Raw Material (Core Application)
N-protected D-leucine monomer for solid-phase / liquid-phase synthesis of D-amino acid containing peptides, enzyme inhibitor polypeptide APIs
2. Chiral Pharmaceutical Intermediate
Chiral building block for anti-infective, antitumor, central nervous system drugs with D-leucine fragment
3. Biochemical Laboratory Reagent
Standard chiral substrate for protease stereoselectivity research, chiral chromatography reference standard
4. Chiral Resolution Auxiliary
Chiral resolving agent for separating racemic amine and carboxylic acid compounds
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 19764-30-8 |
| Molecular Formula | C8H15NO3 |
| Appearance | Uniform white crystal powder without yellow impurities |
| HPLC Purity | Peptide Grade ≥99.0% |
| Melting Point | 186–190 ℃ |
| Specific Optical Rotation | ?18° ~ ?22° (c=2, MeOH) |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.05% |
| D-Isomer Excess | ≥99.5% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 10g/100g vacuum aluminum foil bag, 1kg/5kg light-proof PE lined fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse below 25 ℃, full light shielding, isolate alkaline and oxidizing substances |
| Transportation Requirement | Slightly hygroscopic chiral amino acid derivative, moisture-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed storage |
Safety Warning
Low-toxic mild irritant amino acid crystalline powder. Dust irritates eyes and respiratory mucosa; long-term skin contact may cause slight dryness. All operations carried out in ventilated fume hood with dust mask and nitrile gloves. Avoid mixing with strong oxidants to prevent oxidative discoloration. Waste liquid can be biodegraded after dilution; solid waste classified as general biochemical fine chemical waste for professional disposal.
