Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
β-ESTRADIOL
1. Basic Information
Name: β-Estradiol
Alias: 1,3,5(10)-Estratriene-3,17β-diol, Estradiol
CAS No.: 50-28-2
Molecular Formula: C18H24O2
Molecular Weight: 272.38
Category: Natural estrogen steroid API, hormone pharmaceutical intermediate, biochemical research reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless
- Solubility: Practically insoluble in water; slightly soluble in ethanol, acetone, ether; soluble in vegetable oil, dilute alkaline solution
- Melting Point: 175–178 ℃
- Density (predicted): 1.17 g/cm3
- Hygroscopy: Non-hygroscopic under normal humidity
- Aqueous property: Weakly acidic phenolic hydroxyl group, dissolves in alkali to form soluble phenoxide salt
Chemical Properties
- Molecular structure: Four-ring steroid skeleton, contains two phenolic and alcoholic hydroxyl groups, multiple chiral centers
- Hydroxyl reactivity: Two hydroxyl groups can undergo esterification, etherification, acylation to synthesize estradiol derivatives (estradiol valerate, estradiol benzoate etc.)
- Oxidation characteristic: Phenolic hydroxyl groups easy to oxidize under light and air to form colored quinone impurities
- Optical activity: Strict optical rotation requirement for pharmaceutical grade, single β configuration
- Thermal stability: Stable below 160 ℃; high temperature decomposition produces steroid hydrocarbon fragments
- Photostability: Highly light-sensitive, long-term UV irradiation turns pale yellow-brown
- Compatibility: Compatible with anhydrous polar organic solvents, weak alkaline medium; incompatible with strong oxidants, concentrated mineral acids
3. Main Application Fields
1. Hormone Pharmaceutical API (Core Application)
Raw material for menopausal hormone replacement drugs, female gynecological treatment preparations, transdermal estrogen patches
2. Steroid Pharmaceutical Intermediate
Synthesize estradiol ester derivatives, ethinyl estradiol and other estrogen hormone drugs
3. Biochemical & Pharmacology Research Reagent
Cell culture additive, estrogen receptor experiment standard substance, animal model hormone regulator
4. Veterinary Drug Raw Material
Low-dose additive for livestock reproductive regulation veterinary formulations
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 50-28-2 |
| Molecular Formula | C18H24O2 |
| Appearance | Uniform white crystalline powder without oxidation discoloration |
| HPLC Purity | Pharma Grade ≥99.0% |
| Specific Optical Rotation [α]D20 | +76° ~ +83° (dioxane) |
| Melting Point | 175–178 ℃ |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | 1kg/5kg vacuum aluminum foil bag, 25kg PE lined light-proof fiber drum |
| Storage Condition | Hermetically sealed cool dry warehouse 2–8 ℃, full light shielding, isolate air and oxidants |
| Transportation Requirement | Light-sensitive steroid hormone solid powder, moisture-proof & light-proof sealed packaging |
| Shelf Life | 36 months under nitrogen vacuum sealed low-temperature storage |
Safety Warning
Hormonal active pharmaceutical powder with reproductive interference risk. Dust irritates eyes, nasal tract and respiratory mucosa; skin absorption may disrupt human endocrine balance. All operations must be carried out in fully ventilated fume hood with dust-proof respirator and thick nitrile chemical-resistant gloves. Strict controlled prescription drug raw material, improper exposure or ingestion may cause endocrine disorder, abnormal hormone levels. Waste powder classified as high-risk steroid pharmaceutical hazardous waste, treated by licensed professional institutions after neutralization treatment.
