Tacrolimus-Shandong Huashi Import & Export Co., Ltd.

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Tacrolimus

Brand：HS

Model：25kg/drum

Purity：99%

Cas：104987-11-3

Createtime： 2026-04-14
Updatetime： 2026-09-30

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Product Details

useage	Industrial use
deliveryInfo
appearance	powder
Molecular Weight	804.02
aliasen
supplyCapacity	50000MT/Month
harbor	Qingdao,China
minorder	1KG
Appearance	White to off-white crystalline powder

Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.

Tacrolimus

CAS: 104987-11-3

1. Basic Information

Name: Tacrolimus

Alias: FK506, (3S,4R,5S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S)-5,6,12,14-Tetrahydroxy-3,4,5,6,9,10,11,12,13,14,21,22-dodecahydro-8-methoxy-3,4,10-trimethyl-23-(prop-2-en-1-yl)-1,7-dioxo-1,17-seco-3,19-cyclo-23,24-dinorhomo-1H-indo[3,2-c][1,4]oxaazacyclohenicosine-18-carboxylic acid

CAS No.: 104987-11-3

Molecular Formula: C44H69NO12

Molecular Weight: 804.02

Category: Macrolide immunosuppressant API, transplant anti-rejection drug raw material

2. Physical and Chemical Properties

Physical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless
Solubility: Soluble in methanol, ethanol, acetone, dichloromethane; slightly soluble in hexane; practically insoluble in water
Melting Range: 113–115 ℃
Hygroscopy: Slightly hygroscopic under high humidity
Aqueous Property: Neutral macrolide, insoluble in water, stable in neutral organic solvents

Chemical Properties

Molecular structure: Large polycyclic macrolide containing multiple hydroxyl, ether, ketone, double bond functional groups
Hydroxyl reactivity: Hydroxyl groups can undergo acylation, silylation protection for derivative synthesis
Double bond characteristics: Multiple conjugated double bonds, easy to oxidize under light and air
Optical activity: Multiple chiral centers, high optical purity required for pharmaceutical use
Thermal stability: Stable below 100 ℃; overheating triggers oxidation and decomposition to form related impurities
Photostability: Highly light-sensitive; UV irradiation rapidly produces colored oxidative impurities
Compatibility: Compatible with anhydrous polar organic solvents; incompatible with strong oxidants, concentrated strong acid/alkali

3. Main Application Fields

1. Organ Transplant Immunosuppressant API (Core Application)

Clinical core drug for kidney, liver, heart and other solid organ transplantation, inhibits T lymphocyte activity to reduce postoperative graft rejection; also used for refractory atopic dermatitis topical preparations

2. Immunology Research Reagent

Laboratory tool for immune cell signal pathway research, calcineurin inhibition mechanism study

3. Pharmacopoeia Reference Standard

HPLC standard for related substance and enantiomer detection in tacrolimus production quality control

4. Quality Specification Table

Test Item	Standard Specification
CAS Number	104987-11-3
Molecular Formula	C44H69NO12
Appearance	Uniform white crystalline powder without yellow/brown oxidation impurities
HPLC Purity	Pharma Grade ≥99.0%
Specific Optical Rotation [α]D20	?74° ~ ?84° (MeOH)
Water Content (KF)	≤0.50%
Residue on Ignition	≤0.10%
Single Maximum Unknown Impurity	≤0.05%
Heavy Metals (Pb)	≤10 ppm
Packaging	Nitrogen-filled amber vacuum aluminum foil bags / low-light PE lined fiber drums
Storage Condition	Hermetically sealed cool dry warehouse 2–8 ℃, full light shielding, isolate air and oxidants
Transportation Requirement	Cold-chain light-sensitive macrolide solid, moisture-proof & light-proof sealed packaging
Shelf Life	36 months under nitrogen vacuum sealed low-temperature storage

Safety Warning

Immunosuppressive toxic pharmaceutical powder. Dust irritates eyes, nasal tract and respiratory mucosa; skin absorption may affect immune function. All operations must be carried out in ventilated fume hood with dust-proof respirator and nitrile chemical-resistant gloves. Strict prescription controlled drug, arbitrary oral/skin use may cause infection, renal toxicity, hypertension and other side effects. Waste liquid neutralized before discharge; solid waste classified as high-risk pharmaceutical hazardous waste, disposed by licensed professional institutions.