Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Melanotan II
1. Basic Information
Name: Melanotan II
Alias: MT2, Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
CAS No.: 121062-08-6
Molecular Formula: C50H69N15O9
Molecular Weight: 1024.18
Category: Synthetic cyclic melanocortin peptide, biochemical research reagent
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white lyophilized crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in purified water, dilute acetic acid; soluble in methanol, DMSO; insoluble in ethyl acetate, alkanes
- Melting Character: Decomposes above 230 °C, no distinct melting point
- Hygroscopy: Highly hygroscopic, rapidly absorbs moisture from air
- Aqueous Property: Weakly acidic aqueous solution, stable under sterile low-temperature conditions
Chemical Properties
- Molecular Structure: Cyclic heptapeptide analog of α-MSH, fixed cyclic peptide skeleton with acetylated N-terminus and amide C-terminus, contains D-Phe chiral modification
- Peptide Bond Stability: Stable under neutral/weakly acidic environment; hydrolyzed under strong acid/strong alkali heating to break cyclic ring and fragment amino acids
- Biological Activity Characteristics: High affinity agonist for MC1, MC3, MC4 melanocortin receptors
- Thermal Stability: Stable at 2–8 °C sealed storage; room temperature long-term storage leads to oxidation, discoloration and activity decline
- Photostability: Extremely sensitive to ultraviolet light; illumination causes oxidation of tryptophan residue and loss of biological activity
- Compatibility: Compatible with sterile aqueous buffer, peptide synthesis solvents; incompatible with strong oxidants, heavy metal ions, alkaline environments
3. Main Application Fields
1. Biochemical Pharmacological Research (Core Application)
Laboratory research tool for melanocortin receptor mechanism research; study melanin synthesis, sexual function regulation, appetite and energy metabolism related signal pathways
2. Peptide Reference Standard
HPLC reference substance for cyclic peptide purity and impurity inspection in peptide laboratory
3. Preclinical Drug Candidate Research
Raw material for preclinical research of skin pigmentation, metabolic regulation related candidate drugs
Important Reminder: Melanotan II is not approved as a legal cosmetic or injection drug for human body use in most regions, self-injection has serious safety risks including hypertension, pigmentation disorder, organ damage.
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 121062-08-6 |
| Molecular Formula | C50H69N15O9 |
| Appearance | Uniform white freeze-dried powder without yellow/brown oxidation impurities |
| HPLC Purity | Research Grade ≥98.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.50% |
| Amino Acid Composition | Meet theoretical molar ratio |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-filled amber glass vial, vacuum aluminum foil outer package |
| Storage Condition | Hermetically sealed, 2–8 °C cold storage, completely shaded; strictly avoid moisture and room temperature long-term placement |
| Transportation Requirement | Low-temperature light-proof hygroscopic peptide solid, cold chain sealed transportation |
| Shelf Life | 24 months under sealed low-temperature nitrogen protection |
Safety Warning
Bioactive peptide irritant powder. Dust stimulates eyes, respiratory tract and skin; accidental excessive exposure may cause dizziness, elevated blood pressure and pigmentation changes. All operations must be carried out in ventilated fume hoods with dust-proof respirators and chemical-resistant gloves. Strictly prohibit human injection, oral administration and cosmetic use. Waste liquid neutralized after solvent recovery; solid waste classified as bioactive hazardous waste and disposed by professional licensed institutions.
