L-Serine benzyl ester hydrochloride
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
231.68
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
L-Serine benzyl ester hydrochloride
1. Basic Information
Name: L-Serine benzyl ester hydrochloride
CAS No.: 60022-62-0
Molecular Formula: C10H14ClNO3
Molecular Weight: 231.68
Category: Chiral amino acid derivative peptide synthesis intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slight acidic taste
- Solubility: Soluble in methanol, ethanol, water; slightly soluble in acetone; insoluble in ethyl acetate and alkanes
- Melting Range: 162–166 °C
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous Property: Acidic aqueous solution due to hydrochloride salt
Chemical Properties
- Molecular Structure: L-serine protected with benzyl ester at carboxyl group, forming hydrochloride salt with amino group
- Amino Group Reactivity: Primary amine can carry out acylation, Boc/Fmoc protection, peptide coupling reactions
- Hydroxyl Group Activity: Side chain hydroxyl available for silylation, esterification protection
- Ester Hydrolysis: Benzyl ester stable under neutral mild conditions; hydrolyzed under strong acid/alkali heating to release L-serine
- Thermal Stability: Stable below 100 °C; long-time high temperature leads to partial debenzylation and decomposition
- Photostability: Moderately light-sensitive; long UV exposure causes slight yellow discoloration
- Compatibility: Compatible with common peptide synthesis solvents; incompatible with strong alkali, strong oxidants
3. Main Application Fields
1. Peptide Synthetic Intermediate (Core Application)
Key building block for solid/liquid phase peptide synthesis; benzyl ester acts as carboxyl protecting group for serine-containing polypeptide preparation
2. Chiral Pharmaceutical Intermediate
Raw material for serine-based chiral drugs and small molecule enzyme inhibitors
3. HPLC Chiral Reference Standard
Reference substance for amino acid derivative purity detection
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 60022-62-0 |
| Molecular Formula | C10H14ClNO3 |
| Appearance | Uniform white crystalline powder without foreign impurities |
| HPLC Purity | Peptide Grade ≥99.0% |
| Optical Rotation [α]D20 | -8.0 ~ -10.0 (c=1, MeOH) |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vacuum aluminum foil bags / PE-lined fiber drums |
| Storage Condition | Hermetically sealed cool dark warehouse below 25 °C; isolate from moisture, light and alkaline reagents |
| Transportation Requirement | Hygroscopic chiral amino acid salt solid, moisture-proof light-proof sealed packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum sealed storage |
Safety Warning
Mild irritant amino acid hydrochloride powder. Dust irritates eyes and respiratory tract. All operations shall be performed in ventilated fume hoods with dust respirators and chemical-resistant safety gloves. Airtight storage to prevent moisture absorption. Waste liquid can be neutralized and recycled for solvent recovery; solid waste belongs to general organic chemical waste and disposed by licensed hazardous waste institutions.
