4-BROMOPYRIDIN-2-OL
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
173.99
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
4-Bromo-2-hydroxypyridine
1. Basic Information
Name: 4-Bromo-2-hydroxypyridine
Alias: 4-Bromopyridin-2-ol
CAS No.: 36953-37-4
Molecular Formula: C5H4BrNO
Molecular Weight: 173.99
Category: Brominated pyridine heterocyclic pharmaceutical intermediate
2. Physical and Chemical Properties
Physical Properties
- Appearance: Off-white to pale beige crystalline powder
- Odor: Faint heterocyclic odor
- Solubility: Soluble in methanol, ethanol, DMSO, THF, ethyl acetate; slightly soluble in hot water; insoluble in alkanes
- Melting Range: 210–215 °C
- Hygroscopy: Slightly hygroscopic under high humidity
- Aqueous Property: Weakly acidic aqueous solution due to pyridinol hydroxyl group
Chemical Properties
- Molecular Structure: Pyridine ring with bromine at 4-position and hydroxyl group at 2-position, exists in pyridone tautomer form
- Hydroxyl Reactivity: Capable of O-alkylation, esterification, and condensation reactions
- Aryl Bromide Activity: C-Br bond participates in Suzuki, Buchwald, Sonogashira cross-coupling reactions
- Thermal Stability: Stable below 120 °C; slight decomposition upon long heating above melting point
- Photostability: Sensitive to ultraviolet light; long-term light exposure causes darkening
- Compatibility: Compatible with polar organic solvents; incompatible with strong oxidants and concentrated strong alkali
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key building block for constructing pyridine-containing anti-inflammatory, anti-tumor and kinase inhibitor APIs via palladium-catalyzed coupling reactions
2. Agrochemical Intermediate
Raw material for halogenated pyridine fungicides and insecticides
3. HPLC Reference Standard
Reference substance for detection of bromopyridinol intermediates
4. Quality Specification Table
| Test Item | Standard Specification |
| CAS Number | 36953-37-4 |
| Molecular Formula | C5H4BrNO |
| Appearance | Off-white crystalline powder |
| HPLC Purity | Synthetic Intermediate Grade ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Melting Range | 210–215 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vacuum aluminum foil bags / PE-lined fiber drums |
| Storage Condition | Hermetically sealed dark warehouse below 25 °C; isolated from light, oxidants and alkaline reagents |
| Transportation Requirement | Light-sensitive bromopyridine solid, fully sealed light-proof packaging |
| Shelf Life | 24 months under nitrogen-filled vacuum packaging |
Safety Warning
Irritant brominated pyridine powder. Dust irritates eyes, respiratory tract and skin; prolonged skin contact may trigger allergic dermatitis. All operations must be conducted in ventilated fume hoods with dust respirators, chemical-resistant gloves and full-face safety goggles. Store airtight away from light to avoid photooxidation discoloration. Waste liquid needs solvent recovery and neutralization; solid waste belongs to organic hazardous waste and shall be disposed by licensed professional institutions.
