((1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
109.13
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
(1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one
1. Basic Information
Name: (1R,4S)-2-Azabicyclo[2.2.1]hept-5-en-3-one
Alias: Chiral Vince Lactam
CAS No.: 79200-56-9
Molecular Formula: C6H7NO
Molecular Weight: 109.13
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline solid
- Odor: Faint mild lactam odor
- Solubility: Soluble in CH3OH, C2H5OH, acetone, THF, CHCl3; slightly soluble in hot H2O; insoluble in aliphatic hydrocarbons
- Melting Point: 102–106 °C
- Hygroscopicity: Slightly hygroscopic under high humidity environment
- Aqueous Characteristic: Weakly neutral chiral lactam, slight solubility in hot water
Chemical Properties
- Molecular Structure: Chiral bicyclic lactam with norbornene skeleton, containing C=C double bond and amide carbonyl group
- Amide Reactivity: Amide bond can undergo hydrolysis under strong acid or alkaline heating; N atom enables alkylation and acylation reactions
- Double Bond Activity: Carbon-carbon double bond supports addition, epoxidation and cycloaddition reactions for chiral drug skeleton construction
- Thermal Stability: Stable below 80 °C; partial decomposition occurs with prolonged heating above melting point
- Photostability: Sensitive to ultraviolet light; long-term light exposure generates trace oxidative impurities
- Compatibility: Compatible with most polar organic solvents; incompatible with strong oxidants, concentrated strong alkali and heavy metal ions
3. Main Application Fields
1. Chiral Pharmaceutical Intermediate (Core Application)
Key chiral building block for synthesizing anti-viral drugs, central nervous system medicines and carbocyclic nucleoside APIs
2. Fine Chiral Organic Synthesis
Raw material for asymmetric synthesis of nitrogen-containing bicyclic chiral compounds and chiral ligands
3. HPLC Chiral Reference Standard
Reference substance for chiral purity detection of Vince lactam series intermediates
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 79200-56-9 |
| Molecular Formula | C6H7NO |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Intermediate Grade ≥99.0% |
| Enantiomeric Excess (ee) | ≥99.0% |
| Water Content (KF) | ≤0.30% |
| Melting Range | 102–106 °C |
| Residue on Ignition | ≤0.10% |
| Single Unknown Impurity | ≤0.10% |
| Heavy Metals (Pb1) | ≤10 ppm |
| Packaging | Nitrogen-purged amber aluminum foil vacuum bag / PE-lined fiber drum |
| Storage Condition | Hermetically sealed in cool dark warehouse below 25 °C; strictly moisture-proof, light-proof and isolated from oxidants and alkaline reagents |
| Transportation Requirement | Light-sensitive chiral lactam solid, fully sealed light-proof packaging |
| Shelf Life | 24 months under nitrogen-sealed vacuum packaging |
Safety Warning
Mild irritant chiral lactam solid. Dust irritates eyes, respiratory tract and skin. All operations must be carried out in a ventilated fume hood with dust mask, chemical-resistant gloves and full-face protective goggles. Keep airtight storage to avoid photooxidation and moisture absorption. Waste liquid needs solvent recovery and neutralization treatment; solid waste is classified as organic hazardous waste and must be disposed by professional hazardous waste treatment institutions.
