GROWTH HORMONE, HUMAN
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
22124.12
|
| aliasen |
|
| supplyCapacity |
50000Metric Ton/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White lyophilized powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Growth Hormone, Human
1. Basic Information
Name: Growth Hormone, Human
Alias: Somatotropin, hGH, Recombinant Human Growth Hormone (rhGH), Somatropin
CAS No.: 12629-01-5
Molecular Formula: C990H1529N263O299S7
Molecular Weight: 22124.12
Structural Feature: Single-chain polypeptide containing 191 amino acid residues with two intramolecular disulfide bonds (Cys53-Cys165, Cys182-Cys189)
2. Physical and Chemical Properties
Physical Properties
- Appearance: White amorphous lyophilized powder
- Odor: Odorless biological protein solid
- Solubility: Soluble in neutral/weak alkaline aqueous buffer (pH＞7.2); insoluble in CH3OH, C2H5OH, acetone and all organic lipid solvents
- Isoelectric Point (pI): 4.9–5.2
- Hygroscopicity: Moderately hygroscopic under high humidity
- Aqueous Characteristic: Clear aqueous solution with strong anabolic biological activity; reconstituted solution unstable at room temperature
Chemical Properties
- Molecular Structure: Polypeptide hormone with multiple polar amino acid side chains and two disulfide bonds maintaining spatial conformation
- Enzymatic Hydrolysis: Rapidly degraded by protease in gastric juice; oral administration loses bioactivity completely
- Oxidation Stability: Sulfur-containing cysteine residues prone to oxidation under air and UV light, leading to activity loss
- Thermal Stability: Lyophilized powder stable at 2–8 °C; protein denaturation and irreversible deactivation above 40 °C
- Photostability: Highly light-sensitive; long-term illumination triggers conformational breakdown
- Compatibility: Incompatible with strong acid, strong alkali, heavy metal ions and oxidants; compatible with sterile phosphate buffer for pharmaceutical formulation
3. Main Application Fields
1. Pharmaceutical Active Pharmaceutical Ingredient (Core Application)
- Clinical treatment for children’s growth retardation caused by endogenous growth hormone deficiency, Noonan syndrome and SHOX gene defects
- Therapeutic agent for adult pituitary growth hormone deficiency, severe burn wound repair and muscle wasting disorders
2. Biochemical & Endocrinology Research Reagent
- Cell culture additive to promote cell proliferation and metabolism
- Reference standard for ELISA, radioimmunoassay and HPLC detection of endogenous GH in serum and tissue samples
- Animal model inducer for growth, fat metabolism and IGF-1 signaling pathway research
3. Biomedical Raw Material
Raw material for developing biosimilar injection preparations, hormone detection kits and in vitro cell assay kits
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 12629-01-5 |
| Molecular Formula | C990H1529N263O299S7 |
| Appearance | White lyophilized powder |
| Protein Purity | Pharma Grade ≥97.0%; Reference Standard ≥99.0% |
| Specific Activity | ≥3.5 IU/mg (WHO 1st IRP) |
| Water Content (KF) | ≤3.00% |
| Related Pituitary Hormone Impurities | ≤0.05% |
| Heavy Metals (Pb1) | ≤10 ppm |
| Packaging | Nitrogen-purged amber vials / vacuum aluminum foil bags |
| Storage Condition | Hermetically sealed at -20 °C in dark environment; strictly cold chain, moisture-proof and light-proof |
| Transportation Requirement | Biologically active peptide, cold chain low-temperature sealed transport |
| Shelf Life | 24 months under frozen vacuum storage |
Safety Warning
Biologically active hormonal protein powder. Dust irritates eyes, nasal mucosa and respiratory tract; long-term abnormal exogenous intake disrupts human endocrine balance, causing acromegaly, hyperglycemia and cardiovascular adverse reactions. Operate in Class II biosafety fume hood with dust mask, sterile gloves and full-face protective goggles. Strictly avoid repeated freeze-thaw cycles and light exposure. Waste liquid needs enzyme degradation treatment before discharge; solid waste is classified as biological hazardous waste and must be incinerated by professional institutions.
