Tamoxifen
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
371.52
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Tamoxifen
Alias: (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine
CAS No.: 10540-29-1
Molecular Formula: C26H29NO
Molecular Weight: 371.52
2. Physical and Chemical Properties
Physical Properties
- Appearance: White or off-white crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in ethanol, methanol, chloroform, acetone; slightly soluble in cold water; insoluble in alkane solvents
- Melting Point: 96–98 °C
- Hygroscopicity: Non-hygroscopic under normal ambient humidity
- Optical property: Contains carbon-carbon double bond cis-trans isomerism, clinical effective form is Z-isomer
Chemical Properties
- Molecular structure: Triphenyl ethylene selective estrogen receptor modulator, contains tertiary amine group and ether linkage
- Amine characteristic: Weak alkalinity, can form soluble salt with organic/inorganic acid (tamoxifen citrate for pharmaceutical use)
- Isomerization risk: Long-term light exposure or high temperature converts Z-isomer to inactive E-isomer, reducing drug efficacy
- Thermal stability: Stable below 80 °C; heating above melting point triggers decomposition and impurity generation
- Photostability: Highly sensitive to ultraviolet light, easy to degrade and discolor under illumination
- Compatibility: Compatible with neutral organic solvents and common pharmaceutical excipients; incompatible with strong oxidants, concentrated strong acid
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Selective estrogen receptor antagonist for adjuvant treatment of estrogen receptor positive breast cancer
- Oral tablet raw material for breast cancer postoperative recurrence prevention and advanced breast cancer therapy
- Clinical medicine for ovulation induction in infertility treatment
2. Pharmacological Research Reagent
- Standard reference substance for HPLC detection of SERM drugs in biological samples
- Cell experiment tool for estrogen receptor signaling pathway research
3. Analytical Standard
LC-MS calibration standard for anti-tumor drug residue testing in pharmaceutical preparations
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 10540-29-1 |
| Molecular Formula | C26H29NO |
| Molecular Weight | 371.52 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Z-Isomer Content | ≥98.0% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Nitrogen-filled amber aluminum foil vacuum bag / 25kg PE-lined fiber drum |
| Storage Condition | Hermetic, light-proof cool dry warehouse below 25 °C; strictly avoid sunlight |
| Transportation Requirement | Anti-tumor API solid, light-resistant sealed packaging |
| Shelf Life | 24 months under intact nitrogen-filled light-proof vacuum packaging |
Safety Warning
Hazardous anti-cancer active substance, long-term skin contact or inhalation may cause endocrine disturbance. All operations must be performed in ventilated fume hood with dust mask, chemical-resistant gloves and safety goggles. Waste residues, waste liquid and contaminated packaging belong to cytotoxic hazardous waste and require professional hazardous waste disposal institutions to process. Avoid strong light storage to prevent isomerization and loss of medicinal activity.
