Probenecid
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
285.36
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
White crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Probenecid
Alias: 4-(Dipropylsulfamoyl)benzoic acid
CAS No.: 57-66-9
Molecular Formula: C13H19NO4S
Molecular Weight: 285.36
2. Physical and Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, faint bitter taste
- Solubility: Insoluble in water; soluble in ethanol, acetone, chloroform, dilute alkaline aqueous solution; slightly soluble in methanol
- Melting Point: 198–201 °C
- Hygroscopicity: Non-hygroscopic under normal ambient humidity
- Crystal Form: Fine needle crystals recrystallized from ethanol
Chemical Properties
- Molecular structure: Benzoic acid derivative with dipropylsulfamoyl substituent on para position of benzene ring
- Acid-base property: Weak organic acid, reacts with alkalis to form water-soluble probenecid salts
- Pharmacological characteristic: Inhibits renal tubular organic acid secretion, reduces urinary excretion of penicillin, cephalosporins and uric acid
- Thermal stability: Stable below 160 °C; thermal decomposition occurs above melting point
- Photostability: Stable under normal indoor light; avoid long-term intense UV irradiation
- Compatibility: Compatible with neutral organic solvents and most pharmaceutical excipients; incompatible with strong oxidants, concentrated strong acid and heavy metal ions
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Uricosuric drug for clinical treatment of hyperuricemia and gout
- Adjuvant medicine to increase blood concentration of penicillin and cephalosporin antibiotics by delaying renal excretion
- Raw material for oral tablets and compound pharmaceutical preparations
2. Forensic & Clinical Testing Reference Standard
HPLC/LC-MS calibration standard for detecting uric acid regulators in blood and urine samples
3. Pharmacological Laboratory Reagent
Research tool for renal organic anion transporter (OAT) inhibition experiments
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 57-66-9 |
| Molecular Formula | C13H19NO4S |
| Molecular Weight | 285.36 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.30% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | 25kg PE-lined fiber drum, nitrogen-filled amber aluminum foil vacuum bag |
| Storage Condition | Hermetic, dry warehouse below 25 °C; avoid high temperature and strong light |
| Transportation Requirement | API solid, dust-proof sealed packaging |
| Shelf Life | 36 months under intact sealed packaging |
