Fluoxetine
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
liquid
|
| Molecular Weight |
309.32
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Pale yellow oily liquid
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Fluoxetine
Alias: N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, Prozac
CAS No.: 54910-89-3
Molecular Formula: C17H18F3NO
Molecular Weight: 309.32
2. Physical & Chemical Properties
Physical Properties
- Appearance: Colorless to pale yellow oily liquid; hydrochloride salt is white crystalline powder
- Odor: Odorless
- Solubility: Free base soluble in methanol, ethanol, acetone, chloroform, ethyl acetate; slightly soluble in hexane; insoluble in water; hydrochloride salt soluble in water and methanol
- Density (25℃): 1.13 g/cm3
- Predicted Boiling Point: 395.1±42.0 °C
- Flash Point: 192.7±27.9 °C
- Optical characteristic: Chiral molecule, exists as racemic mixture in commercial raw material
- Hygroscopy: Non-hygroscopic; hydrochloride form slightly hygroscopic under high humidity
- Refractive Index nD2?: 1.485–1.490
- Storage temperature: Room temperature sealed storage, avoid high temperature
Chemical Properties
- Molecular structure: Contains trifluoromethyl phenyl ether group, secondary amine structure, single chiral carbon center
- Alkalinity: Aliphatic secondary amine group presents weak alkalinity, can form stable hydrochloride salt with hydrochloric acid
- Thermal stability: Stable below 120°C; long-term heating above 150°C causes dealkylation and ether bond cleavage to produce related impurities
- pH stability: Stable under neutral and weak alkaline conditions; strong acid heating promotes hydrolysis of ether linkage
- Photostability: Avoid long-term intense UV irradiation; light triggers oxidation and color darkening
- Fluorine group property: Trifluoromethyl group has strong electron-withdrawing effect, improves metabolic stability of the drug in vivo
- Compatibility: Compatible with common pharmaceutical organic solvents and excipients; incompatible with strong oxidants, concentrated strong acid, acid halides
3. Main Application Fields
1. Clinical Antidepressant API (Core Application)
Highly selective serotonin reuptake inhibitor (SSRI). Blocks central nervous system serotonin reuptake transporter, increases synaptic serotonin concentration to regulate mood.
- Indications: Major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, bulimia nervosa, premenstrual dysphoric disorder
- Medication advantage: Mild side effects, low addiction risk, long half-life for once-daily oral administration
- Dosage forms: Oral tablets, capsules, oral liquid (fluoxetine hydrochloride formulation)
2. Pharmaceutical Intermediate Raw Material
- Bulk drug raw material for fluoxetine hydrochloride finished pharmaceutical preparations
- Structural modification precursor for novel SSRI antidepressant analogues, used for new psychiatric drug screening
3. Biochemical Research Tool Compound
- Specific serotonin transporter inhibitor probe for neuroscience research
- Cell model experimental reagent for studying mood regulation, neurotransmitter transport mechanism
4. Pharmaceutical Reference Standard
High-purity standard substance for HPLC impurity detection, finished product quality control, pharmaceutical factory process verification
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 54910-89-3 |
| Molecular Formula | C17H18F3NO |
| Molecular Weight | 309.32 |
| Appearance | Pale yellow oily liquid (free base); white crystal (hydrochloride) |
| HPLC Purity | Pharma Grade ≥99.0%; USP/EP Grade 98.0%–102.0% |
| Moisture Content (KF) | ≤0.20% |
| Single Unknown Related Impurity | ≤0.10% |
| Total Related Impurities | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Residual Organic Solvents | Compliant with ICH Q3C limit standards |
| Bulk Package | 5kg / 25kg nitrogen-filled lined steel drum |
| Storage Condition | Hermetic sealed dark warehouse ≤25℃; isolate strong light, high temperature and acidic gas |
| Transportation Rule | General pharmaceutical raw material, light-proof and sealed packaging |
| Shelf Life | 24 months under intact sealed packaging |
