1. Basic Product Profile

• Full IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
• Aliases: Fluconazole, UK-49858
• CAS Number: 86386-73-4
• EINECS: N/A
• Molecular Formula: C13H12F2N6O
• Molecular Weight: 306.28
• Chemical Classification: Triazole antifungal API, pharmaceutical raw material, broad-spectrum antifungal intermediate
• Core Advantages
  Difluorophenyl bis-triazole antifungal active pharmaceutical ingredient with high oral bioavailability, broad-spectrum inhibitory activity against Candida, Cryptococcus and dermatophytes. Low liver toxicity, excellent water solubility for oral tablets, capsules and intravenous injection formulations. Widely used in systemic fungal infection treatment, gynecological mycosis, skin fungal disease and cryptococcal meningitis therapy. Stable crystal form, high chiral purity, easy formulation processing.

2. Physical & Chemical Properties

2.1 Physical Index

1. Appearance: White or off-white crystalline powder
2. Odor: Odorless
3. Solubility: Slightly soluble in water; freely soluble in methanol, ethanol, acetone, chloroform; insoluble in alkane solvents
4. Melting Point: 137–141 °C
5. pH (saturated aqueous solution): 6.0–7.2 (neutral)
6. Hygroscopy: Non-hygroscopic under normal dry storage
7. UV characteristic: Characteristic absorption peak at 261 nm

2.2 Chemical Properties

1. Functional groups: Two 1,2,4-triazole rings, difluorobenzene ring, tertiary hydroxyl group
2. Triazole ring activity: Nitrogen atoms on triazole form hydrogen bonds with fungal cytochrome P450 enzyme to inhibit ergosterol synthesis
3. Hydroxyl stability: Tertiary hydroxyl group stable under neutral/weak acid/weak alkali; no dehydration under conventional storage
4. Fluorine substitution: Aromatic C-F bonds stable, resistant to hydrolysis under mild conditions
5. Thermal Stability: Stable below 120°C; prolonged heating above melting point causes slight decomposition
6. Acid & Alkali Stability: Stable pH 3–9; concentrated strong acid long-time heating triggers triazole ring hydrolysis
7. Photostability: Slightly yellow after long-term intense UV irradiation; store light-proof
8. Compatibility: Compatible with common pharmaceutical excipients; incompatible with strong oxidants, concentrated mineral acids

3. Main Application Fields

3.1 Human Antifungal API (Core Usage)

1. Oral preparations: Tablets, capsules, oral suspension for systemic candidiasis, vaginal candidiasis, skin tinea infection;
2. Injectable formulations: IV fluconazole injection for severe systemic fungal infection, cryptococcal meningitis;
3. Prophylactic antifungal medicine for immunocompromised patients.

3.2 Veterinary Pharmaceutical Raw Material

3.3 Biochemical Research Reagent

3.4 Synthetic Intermediate Reference

4. Quality Specification Table