1. Basic Product Profile

• Full IUPAC Name: 1-deoxy-1-(methylamino)-D-glucitol
• Aliases: N-Methyl-D-glucamine, Methylglucamine
• CAS Number: 6284-40-8
• EINECS: 228-506-9
• Molecular Formula: C7H17NO5
• Molecular Weight: 195.21
• Chemical Classification: Polyhydroxy alkylamine, pharmaceutical excipient, contrast medium raw material, solubility booster, analytical reagent
• Core Advantages
  Polyhydroxy chiral amine derived from D-glucose, with multiple hydroxyl groups and a secondary methylamino group. Excellent water solubility, strong ability to form soluble salts with acidic drugs, low toxicity and high biocompatibility. Widely used to prepare meglumine salt APIs (anti-inflammatory, contrast agents), solubilizer for poorly soluble pharmaceuticals, pH buffer stabilizer, and analytical chromatography additive.

2. Physical & Chemical Properties

2.1 Physical Index

1. Appearance: White crystalline powder
2. Odor: Odorless
3. Solubility: Freely soluble in water; soluble in hot methanol; slightly soluble in cold ethanol; insoluble in acetone, ether, hydrocarbons
4. Melting Point: 128–132 °C
5. Specific Optical Rotation [α]D20: -16.0° ~ -18.0° (c=10, water)
6. pH (10% aqueous solution): 9.0–10.5 (weakly alkaline)
7. Hygroscopy: Moderately hygroscopic, absorbs moisture in high humidity air

2.2 Chemical Properties

1. Functional groups: 5 aliphatic hydroxyl groups + secondary methylamino group, chiral polyhydroxy amine structure
2. Salt-forming characteristic: Secondary amine reacts with organic/inorganic acids to generate highly water-soluble meglumine salts (core application for contrast media & injectable drugs)
3. Hydroxyl reactivity: Multiple -OH groups enable esterification, chelation with metal ions, strong hydrogen bonding for solubilization
4. Thermal Stability: Stable below 110°C; prolonged heating above melting point triggers slight caramelization yellowing
5. Acid & Alkali Stability: Stable in neutral/weak alkaline environment; concentrated strong acid heating causes sugar backbone hydrolysis
6. Photostability: Slightly yellow after long-term intense UV irradiation
7. Compatibility: Compatible with water-soluble pharmaceutical raw materials, polar solvents; incompatible with strong oxidants, concentrated mineral acids

3. Main Application Fields

3.1 Medical Contrast Medium Raw Material (Core Usage)

3.2 Pharmaceutical Excipient & Drug Solubilizer

1. Form meglumine salt with poorly water-soluble acidic active pharmaceutical ingredients (NSAIDs, antibiotics) to boost solubility for oral/injectable formulations;
2. pH regulator and stabilizer for injection solutions, reduces irritation to blood vessels.

3.3 Analytical & Biochemical Reagent

1. Mobile phase additive for ion-exchange chromatography;
2. Chelating agent for trace metal detection experiments;
3. Standard reference for sugar amine chiral analysis.

3.4 Fine Chemical Synthesis

4. Quality Specification Table