N-Acetyl-L-cysteine ethyl ester
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
liquid
|
| Molecular Weight |
191.25
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Pale yellow oily liquid
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: ethyl (2R)-2-acetamido-3-sulfanylpropanoate
- Aliases: Ethyl N-acetyl-L-cysteinate, NAC ethyl ester
- CAS Number: 59587-09-6
- EINECS: N/A
- Molecular Formula: C7H13NO3S
- Molecular Weight: 191.25
- Chemical Classification: Lipophilic thiol antioxidant, amino acid derivative, pharmaceutical intermediate, cell protective reagent
- Core Advantages
Lipophilic ethyl ester prodrug of N?acetyl?L?cysteine (NAC). Ester group improves cell membrane permeability compared to water-soluble NAC; free thiol group provides strong ROS scavenging, anti-inflammatory and mucolytic activity. Easily hydrolyzed intracellularly to release active NAC. Widely used in antioxidant research, cosmetic anti-aging raw materials, liver protection drug intermediates and biochemical lab reagents.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Colorless to pale yellow clear oily liquid / low-melting crystal
- Odor: Mild sulfurous thiol odor
- Solubility: Soluble in ethanol, methanol, DMSO, ethyl acetate, toluene; slightly soluble in cold water, freely soluble in hot water
- Melting Point: 18–22 °C
- Density (20℃): 1.126 g/cm3
- Refractive Index nD20: 1.482–1.486
- Hygroscopy: Slightly hygroscopic; thiol easily oxidized by air
- Optical activity: L-configured chiral compound, levorotatory
2.2 Chemical Properties
- Functional groups: Acetamide group, ethyl carboxylate, free thiol (-SH) chiral carbon skeleton
- Thiol oxidation: -SH rapidly oxidizes in air to form disulfide dimer; must be stored under inert gas
- Ester hydrolysis: Acid/alkali catalyzed cleavage yields N?acetyl?L?cysteine and ethanol; intracellular esterase hydrolyzes to active NAC
- Acetamide stability: Amide bond stable under neutral/mild acidic conditions; hydrolyzes under strong heating alkali
- Metal chelation: Thiol group binds heavy metal ions for detoxification
- Acid & Alkali Stability: Stable anhydrous neutral storage; fast oxidation in aqueous alkaline environment
- Thermal Stability: Stable below 80 °C; above 100 °C accelerates oxidation and ester degradation
- Compatibility: Compatible with anhydrous polar organic solvents; incompatible with air, oxidants, heavy metal salts, strong aqueous alkali
3. Main Application Fields
3.1 Biochemical & Pharmacology Research (Core Usage)
- Lipophilic antioxidant probe for cell culture; penetrates cell membrane to eliminate reactive oxygen species;
- Oxidative stress model protective agent for liver, lung and neuronal cell experiments;
- Prodrug research intermediate for mucolytic and anti-fibrosis formulations.
3.2 Cosmetic Active Raw Material
Oil-soluble antioxidant for anti-aging essence, repair cream; inhibits melanin oxidation, reduces free radical skin damage.
3.3 Pharmaceutical Intermediate
Synthetic precursor for thiol-based detoxification, respiratory and liver-protecting oral/transdermal preparations.
3.4 Synthetic Chemistry Reagent
Chiral thiol building block for asymmetric synthesis and disulfide compound construction.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 59587-09-6 |
| Molecular Formula | C7H13NO3S |
| Molecular Weight | 191.25 |
| Appearance | Pale yellow oily liquid |
| HPLC Chiral Purity | Research Grade ≥99.0%; Pharma Grade ≥99.5% |
| Water Content (KF) | ≤0.10% |
| Disulfide Oxidized Impurity | ≤0.20% |
| Free NAC Residue | ≤0.10% |
| Heavy Metals (Pb) | ≤5 ppm |
| Residue on Evaporation | ≤0.05% |
| Bulk Package | Nitrogen-sealed 25L/200L steel drum |
| Sample Package | 100mL / 1L argon-filled light-proof metal bottle |
| Storage Requirements | Hermetic inert gas sealed cool warehouse ≤20℃; isolate air, light, oxidants and heat sources |
| Transportation Rule | Sulfur-containing amino ester intermediate; sealed oxygen-isolated packaging required during transit |
| Shelf Life | 12 months under intact nitrogen-sealed packaging |
