tert-Butyldimethylsilyl chloride
- Createtime： 2026-04-14
- Updatetime： 2026-07-24
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
liquid
|
| Molecular Weight |
150.72
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Colorless transparent liquid
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: tert-butyldimethylchlorosilane
- Aliases: TBSCl, TBDMSCl, tert-Butyldimethylsilyl chloride
- CAS Number: 18162-48-6
- EINECS: 242-069-3
- Molecular Formula: C6H15ClSi
- Molecular Weight: 150.72
- Chemical Classification: Silane protecting group reagent, hydroxyl blocking agent, organic synthesis intermediate
- Core Advantages
Classic silicon-based hydroxyl protecting reagent with moderate steric hindrance. Selectively masks primary, secondary and phenolic hydroxyl groups under mild conditions; stable to oxidation, reduction and weak acid/alkali; easily deprotected by tetrabutylammonium fluoride (TBAF). Widely used in pharmaceutical chiral intermediates, polyimide monomers, natural product total synthesis and optoelectronic material preparation.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Colorless transparent liquid
- Odor: Irritating pungent silicon chloride odor
- Solubility: Miscible with DCM, THF, DMF, toluene, hexane; violently reacts with water, methanol, ethanol
- Boiling Point: 124–126 °C
- Density (20℃): 0.87 g/cm3
- Refractive Index nD20: 1.418
- Hygroscopy: Extremely moisture-sensitive, instant hydrolysis releases HCl gas when exposed to water vapor
2.2 Chemical Properties
- Active Si-Cl bond: Reacts with -OH, -NH2 under base catalysis to form stable TBS ether/silylamine protective groups
- Steric hindrance feature: Tert-butyl group provides steric shielding, improves stability of protected intermediates in multi-step synthesis
- Hydrolysis characteristic: Rapidly hydrolyzes in protic solvents/water to generate tert-butyldimethylsilanol and hydrogen chloride
- Acid & Alkali Stability: Stable under anhydrous neutral/weak alkaline environment; decomposed by water, dilute acid and fluoride ions
- Thermal Stability: Stable below 100 °C; slow disproportionation above 130 °C
- Compatibility: Compatible with anhydrous aprotic solvents; strictly incompatible with water, alcohols, amines, fluoride salts
3. Main Application Fields
3.1 Pharmaceutical Intermediate Synthesis (Core Usage)
Universal hydroxyl protective reagent for complex chiral APIs, steroid drugs, macrolide antibiotics and natural product synthetic routes; avoids side reactions of hydroxyl groups in coupling, oxidation and reduction steps.
3.2 Organic Optoelectronic Material Manufacturing
Mask hydroxyl groups of fluorinated polyimide monomers and conjugated luminescent materials during purification and derivatization.
3.3 Laboratory Synthetic Research Reagent
Standard silyl protecting reagent for university organic chemistry labs and fine chemical pilot processes.
3.4 Silicone Chemical Intermediate
Raw material for synthesizing tert-butyldimethylsilyl functional silicone oil and silicone surfactants.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 18162-48-6 |
| Molecular Formula | C6H15ClSi |
| Molecular Weight | 150.72 |
| Appearance | Colorless transparent liquid |
| GC Purity | Synthesis Grade ≥98.0%; Electronic Grade ≥99.0% |
| Moisture Content (KF) | ≤100 ppm |
| Free HCl | ≤0.05% |
| Residue on Evaporation | ≤0.01% |
| Bulk Package | 200L nitrogen-sealed pressure-resistant steel drum |
| Sample Package | 1L / 5L argon-filled sealed metal bottle |
| Storage Requirements | Hermetic inert gas sealed low-humidity warehouse ≤25℃; fully isolate air, moisture and protic solvents |
| Transportation Rule | Moisture-sensitive corrosive silane reagent; nitrogen-filled fully sealed acid-resistant packaging mandatory during transit |
| Shelf Life | 24 months under intact argon-sealed packaging |
