ISOCARBOXAZID (200 MG)
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
231.25
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Off-white crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-Benzyl-2-methylhydrazide of 3-methylisoxazole-5-carboxylic acid
- Aliases: Isocarboxazid, Marplan
- CAS Number: 59-63-2
- EINECS: 200-438-8
- Molecular Formula: C12H13N3O2
- Molecular Weight: 231.25
- Chemical Classification: Monoamine Oxidase Inhibitor API, isoxazole hydrazide psychiatric bulk drug
- Core Advantages
Irreversible non-selective MAO inhibitor active pharmaceutical ingredient. Blocks monoamine oxidase enzyme to elevate brain serotonin, norepinephrine and dopamine levels, indicated for clinical depression treatment. Strictly complies with USP/EP pharmacopoeia purity standards, supplied as raw material for oral tablet formulations and laboratory pharmacological research reference standards.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Off-white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in ethanol, methanol, DMSO; practically insoluble in water, aliphatic alkanes
- Melting Point: 105–108 °C
- Hygroscopy: Non-hygroscopic under dry sealed storage
- Optical Character: No chiral carbon, achiral compound
2.2 Chemical Properties
- Isoxazole Hydrazide Skeleton: Hydrazide functional group is the core moiety responsible for MAO inhibitory bioactivity
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; hydrazide hydrolysis occurs under prolonged heating with strong alkaline aqueous solution
- Thermal Stability: Slow decomposition above 130°C, generates volatile nitrogen-containing impurities
- Photostability: Sensitive to intense UV light; long-term light exposure triggers yellow discoloration and related substance generation
- Compatibility: Compatible with neutral solid pharmaceutical excipients; incompatible with strong oxidants, concentrated mineral acids and heavy metal salts
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
Active raw material for oral antidepressant tablets, clinically prescribed for refractory major depressive disorder as monoamine oxidase inhibitor therapeutic agent.
3.2 Pharmacological Research Reagent
Standard MAO inhibitor substrate for neuroscience laboratory experiments studying monoamine neurotransmitter metabolism and depression mechanism research.
3.3 Pharmaceutical Quality Control Reference Standard
HPLC calibration reference substance for purity testing of isocarboxazid bulk drug and finished tablet formulations.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 59-63-2 |
| Molecular Formula | C12H13N3O2 |
| Molecular Weight | 231.25 |
| Appearance | Off-white crystalline powder |
| Melting Range | 105–108 °C |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof nitrogen-sealed aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, strong light and oxidizing substances |
| Transportation Rule | Non-hazardous psychiatric API; light-proof waterproof sealed packaging mandatory during transit |
| Shelf Life | 36 months under intact nitrogen-sealed light-proof packaging |
