Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-, monosodium salt
- Createtime： 2026-04-14
- Updatetime： 2026-09-30
Product Details
| useage |
Industrial use
|
| deliveryInfo |
|
| appearance |
powder
|
| Molecular Weight |
263.27
|
| aliasen |
|
| supplyCapacity |
50000MT/Month
|
| harbor |
Qingdao,China
|
| minorder |
1KG
|
| Appearance |
Off-white to pale beige crystalline powder
|
Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: Sodium 2-[(2,3-dimethylphenyl)amino]benzoate
- Aliases: Sodium Mefenamate, Mefenamic Acid Sodium Salt, Sodium N-(2,3-xylyl)anthranilate
- CAS Number: 1804-47-3
- EINECS: N/A
- Molecular Formula: C15H14NNaO2
- Molecular Weight: 263.27
- Chemical Classification: NSAID pharmaceutical salt intermediate, fenamate class sodium salt, oral solubility-improved drug precursor
- Core Advantages
Sodium salt form of mefenamic acid anthranilic acid derivative. Significantly higher aqueous solubility than free mefenamic acid, delivering faster oral dissolution and absorption in vivo. Retains COX inhibitory anti-inflammatory, analgesic and antipyretic bioactivity. Key raw material for soluble oral NSAID formulations and pharmaceutical impurity reference standards, compliant with pharmaceutical research synthesis specifications.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Off-white to pale beige crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, methanol, ethanol, DMSO; slightly soluble in acetone; insoluble in aliphatic hydrocarbons
- Melting Range: 285–290 °C (decomposition)
- Aqueous Solution pH: 7.5–9.0 (weak alkaline)
- Hygroscopy: Slightly hygroscopic under high humidity environment
- Crystal Feature: Uniform fine crystalline powder with excellent formulation dispersibility
2.2 Chemical Properties
- Anthranilate Sodium Salt Structure: Ionized carboxylate group enables high water solubility; secondary aromatic amine maintains core NSAID pharmacophore
- Salt-Acid Equilibrium: Reacts with mineral acid to precipitate free mefenamic acid
- Acid & Alkali Stability: Stable under neutral and weak alkaline storage; hydrolyzes under strong acid heating; long-term heating with concentrated alkali causes partial aromatic ring degradation
- Photostability: Sensitive to intense UV light; prolonged light exposure triggers discoloration and minor impurity generation
- Compatibility: Compatible with neutral pharmaceutical excipients and polar aqueous solvents; incompatible with strong mineral acids, heavy metal ions and cationic surfactants
3. Main Application Fields
3.1 Pharmaceutical Formulation Raw Material (Core Usage)
Soluble sodium salt precursor for oral anti-inflammatory analgesic tablets, suspensions and liquid preparations; improves dissolution rate of mefenamic acid for treatment of mild-moderate pain, primary dysmenorrhea and rheumatoid inflammation.
3.2 Pharmaceutical Quality Control Reference Standard
HPLC impurity reference substance for mefenamic acid bulk drug detection in pharmaceutical QC laboratories and drug R&D institutions.
3.3 Pharmacological Research Reagent
Water-soluble COX inhibitor substrate for in vitro anti-inflammatory activity screening experiments in academic pharmacology labs.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 1804-47-3 |
| Molecular Formula | C15H14NNaO2 |
| Molecular Weight | 263.27 |
| Appearance | Off-white to pale beige crystalline powder |
| Melting Range | 285–290 °C (decompose) |
| HPLC Chemical Purity | Synthesis Grade ≥99.0%; Reference Standard Grade ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined nitrogen-sealed fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof refrigerated warehouse (2–8°C); isolate humid air, intense light and acidic substances |
| Transportation Rule | Non-hazardous pharmaceutical salt intermediate; light-proof waterproof packaging mandatory during transit |
| Shelf Life | 36 months under intact nitrogen-sealed light-proof packaging |
